HK1 (hexokinase 1)

Identity

HGNC

HK1

LOCATION

10q22.1

LOCUSID

3098

ALIAS

HK,HK1-ta,HK1-tb,HK1-tc,HKD,HKI,HMSNR,HXK1,NEDVIBA,RP79,hexokinase

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 3098
MIM: 142600
HGNC: 4922
Ensembl: ENSG00000156515

Variants:

dbSNP: 3098
ClinVar: 3098
TCGA: ENSG00000156515
COSMIC: HK1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000156515	ENST00000298649	P19367
ENSG00000156515	ENST00000359426	P19367
ENSG00000156515	ENST00000360289	P19367
ENSG00000156515	ENST00000421088	B1AR62
ENSG00000156515	ENST00000436817	P19367
ENSG00000156515	ENST00000436817	A0A024QZK7
ENSG00000156515	ENST00000448642	P19367
ENSG00000156515	ENST00000448642	A0A024QZK7
ENSG00000156515	ENST00000450646	P78542
ENSG00000156515	ENST00000464803	A0A2R8Y7T9

Previous1 2Next

Expression (GTEx)

0

50

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Amino sugar and nucleotide sugar metabolism	KEGG	ko00520
Amino sugar and nucleotide sugar metabolism	KEGG	hsa00520
Carbohydrate digestion and absorption	KEGG	ko04973
Carbohydrate digestion and absorption	KEGG	hsa04973
Carbon metabolism	KEGG	hsa01200
Carbon metabolism	KEGG	ko01200
Central carbon metabolism in cancer	KEGG	hsa05230
Central carbon metabolism in cancer	KEGG	ko05230
Fructose and mannose metabolism	KEGG	ko00051
Fructose and mannose metabolism	KEGG	hsa00051

Previous1 2 3 4Next

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36639056	2023	Expanding the neurodevelopmental phenotype associated with HK1 de novo heterozygous missense variants.	1
36639056	2023	Expanding the neurodevelopmental phenotype associated with HK1 de novo heterozygous missense variants.	1
36938709	2023	Targeting hexokinase 1 alleviates NLRP3-mediated inflammation in apical periodontitis: A laboratory investigation.	2
36938709	2023	Targeting hexokinase 1 alleviates NLRP3-mediated inflammation in apical periodontitis: A laboratory investigation.	2
37834257	2023	Intermittent Hypoxia Promotes TAM-Induced Glycolysis in Laryngeal Cancer Cells via Regulation of HK1 Expression through Activation of ZBTB10.	0
37834257	2023	Intermittent Hypoxia Promotes TAM-Induced Glycolysis in Laryngeal Cancer Cells via Regulation of HK1 Expression through Activation of ZBTB10.	0
37973885	2023	Hemokinin-1 is a mediator of chronic restraint stress-induced pain.	0
37973885	2023	Hemokinin-1 is a mediator of chronic restraint stress-induced pain.	0
38016997	2023	Proteomic analyses identify HK1 and ATP5A to be overexpressed in distant metastases of lung adenocarcinomas compared to matched primary tumors.	0
38016997	2023	Proteomic analyses identify HK1 and ATP5A to be overexpressed in distant metastases of lung adenocarcinomas compared to matched primary tumors.	0

Previous1 2Next

Citation

Dessen P

HK1 (hexokinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47112