HK1 (hexokinase 1)

2007-04-01  

Identity

HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
HK,HK1-ta,HK1-tb,HK1-tc,HKD,HKI,HMSNR,HXK1,NEDVIBA,RP79,hexokinase
FUSION GENES

Other Information

Locus ID:

NCBI: 3098
MIM: 142600
HGNC: 4922
Ensembl: ENSG00000156515

Variants:

dbSNP: 3098
ClinVar: 3098
TCGA: ENSG00000156515
COSMIC: HK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156515ENST00000298649P19367
ENSG00000156515ENST00000359426P19367
ENSG00000156515ENST00000360289P19367
ENSG00000156515ENST00000421088B1AR62
ENSG00000156515ENST00000436817P19367
ENSG00000156515ENST00000436817A0A024QZK7
ENSG00000156515ENST00000448642P19367
ENSG00000156515ENST00000448642A0A024QZK7
ENSG00000156515ENST00000450646P78542
ENSG00000156515ENST00000464803A0A2R8Y7T9
ENSG00000156515ENST00000476368A0A2R8YEE7
ENSG00000156515ENST00000493591A0A2R8Y626
ENSG00000156515ENST00000643399P19367
ENSG00000156515ENST00000643399A0A024QZK7

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Fructose and mannose metabolismKEGGko00051
Galactose metabolismKEGGko00052
Starch and sucrose metabolismKEGGko00500
Amino sugar and nucleotide sugar metabolismKEGGko00520
Insulin signaling pathwayKEGGko04910
Type II diabetes mellitusKEGGko04930
Glycolysis / GluconeogenesisKEGGhsa00010
Fructose and mannose metabolismKEGGhsa00051
Galactose metabolismKEGGhsa00052
Starch and sucrose metabolismKEGGhsa00500
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Insulin signaling pathwayKEGGhsa04910
Type II diabetes mellitusKEGGhsa04930
Metabolic pathwaysKEGGhsa01100
Neomycin, kanamycin and gentamicin biosynthesisKEGGko00524
Neomycin, kanamycin and gentamicin biosynthesisKEGGhsa00524
Carbohydrate digestion and absorptionKEGGko04973
Carbohydrate digestion and absorptionKEGGhsa04973
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGhsa_M00001
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGM00001
Nucleotide sugar biosynthesis, glucose => UDP-glucoseKEGGhsa_M00549
Nucleotide sugar biosynthesis, glucose => UDP-glucoseKEGGM00549
HIF-1 signaling pathwayKEGGhsa04066
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Hexose transportREACTOMER-HSA-189200
Glucose transportREACTOMER-HSA-70153
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GlycolysisREACTOMER-HSA-70171

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380436692024DDX24 promotes tumor progression by mediating hexokinase-1 induced glycolysis in gastric cancer.0
380436692024DDX24 promotes tumor progression by mediating hexokinase-1 induced glycolysis in gastric cancer.0
366390562023Expanding the neurodevelopmental phenotype associated with HK1 de novo heterozygous missense variants.1
369387092023Targeting hexokinase 1 alleviates NLRP3-mediated inflammation in apical periodontitis: A laboratory investigation.2
378342572023Intermittent Hypoxia Promotes TAM-Induced Glycolysis in Laryngeal Cancer Cells via Regulation of HK1 Expression through Activation of ZBTB10.0
379738852023Hemokinin-1 is a mediator of chronic restraint stress-induced pain.0
380169972023Proteomic analyses identify HK1 and ATP5A to be overexpressed in distant metastases of lung adenocarcinomas compared to matched primary tumors.0
382927642023Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complications.0
383010922023Expanding the Molecular Spectrum of HK1-Related Charcot-Marie-Tooth Disease, Type 4G; the First Report in Iran.0
366390562023Expanding the neurodevelopmental phenotype associated with HK1 de novo heterozygous missense variants.1
369387092023Targeting hexokinase 1 alleviates NLRP3-mediated inflammation in apical periodontitis: A laboratory investigation.2
378342572023Intermittent Hypoxia Promotes TAM-Induced Glycolysis in Laryngeal Cancer Cells via Regulation of HK1 Expression through Activation of ZBTB10.0
379738852023Hemokinin-1 is a mediator of chronic restraint stress-induced pain.0
380169972023Proteomic analyses identify HK1 and ATP5A to be overexpressed in distant metastases of lung adenocarcinomas compared to matched primary tumors.0
382927642023Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complications.0

Citation

Dessen P

HK1 (hexokinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47112/