ADAM22 (ADAM metallopeptidase domain 22)

2007-04-01  

Identity

HGNC
ADAM22
LOCATION
7q21.12
LOCUSID
53616
ALIAS
ADAM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 53616
MIM: 603709
HGNC: 201
Ensembl: ENSG00000008277

Variants:

dbSNP: 53616
ClinVar: 53616
TCGA: ENSG00000008277
COSMIC: ADAM22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008277ENST00000265727Q9P0K1
ENSG00000008277ENST00000398201Q9P0K1
ENSG00000008277ENST00000398203F8WAD8
ENSG00000008277ENST00000398204Q9P0K1
ENSG00000008277ENST00000398209Q9P0K1
ENSG00000008277ENST00000412441E9PF78
ENSG00000008277ENST00000413139H7C3I4
ENSG00000008277ENST00000426930H7C0Q9
ENSG00000008277ENST00000439864E7EPF1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
LGI-ADAM interactionsREACTOMER-HSA-5682910

References

Pubmed IDYearTitleCitations
385187312024ADAM22 acts as a novel predictive biomarker for unfavorable prognosis and facilitates metastasis via PI3K/AKT signaling pathway in nasopharyngeal carcinoma.0
385187312024ADAM22 acts as a novel predictive biomarker for unfavorable prognosis and facilitates metastasis via PI3K/AKT signaling pathway in nasopharyngeal carcinoma.0
353738132022Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy.8
353738132022Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy.8
316270332020LGI3 is secreted and binds to ADAM22 via TRIF-dependent NF-κB pathway in response to LPS in human keratinocytes.4
332081582020ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis.4
316270332020LGI3 is secreted and binds to ADAM22 via TRIF-dependent NF-κB pathway in response to LPS in human keratinocytes.4
332081582020ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis.4
296701002018Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.31
302784492018miR-449a Suppresses Tamoxifen Resistance in Human Breast Cancer Cells by Targeting ADAM22.24
296701002018Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.31
302784492018miR-449a Suppresses Tamoxifen Resistance in Human Breast Cancer Cells by Targeting ADAM22.24
277601372016Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 Receptors.8
277601372016Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 Receptors.8
238100132013ADAM22 as a prognostic and therapeutic drug target in the treatment of endocrine-resistant breast cancer.11

Citation

Dessen P

ADAM22 (ADAM metallopeptidase domain 22)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47115/adam22-(adam-metallopeptidase-domain-22)