TOX (thymocyte selection associated high mobility group box)

2007-04-01  

Identity

HGNC
TOX
LOCATION
8q12.1
LOCUSID
9760
ALIAS
TOX1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9760
MIM: 606863
HGNC: 18988
Ensembl: ENSG00000198846

Variants:

dbSNP: 9760
ClinVar: 9760
TCGA: ENSG00000198846
COSMIC: TOX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198846ENST00000361421O94900

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379329312024TOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage mycosis fungoides.0
380876462024TOX as a new diagnostic marker for T cell large granular lymphocytic leukaemia.0
379329312024TOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage mycosis fungoides.0
380876462024TOX as a new diagnostic marker for T cell large granular lymphocytic leukaemia.0
357135022023TOX promotes follicular helper T cell differentiation in patients with primary Sjögren's syndrome.4
360420472023Immune checkpoint receptor VISTA on immune cells is associated with expression of T-cell exhaustion marker TOX and worse prognosis in renal cell carcinoma with venous tumor thrombus.6
369330412023High TOX expression on CD8(+) T cells in pure red cell aplasia.0
369692162023TOX regulates T lymphocytes differentiation and its function in tumor.2
379619482023Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in Acute Leukemia.0
357135022023TOX promotes follicular helper T cell differentiation in patients with primary Sjögren's syndrome.4
360420472023Immune checkpoint receptor VISTA on immune cells is associated with expression of T-cell exhaustion marker TOX and worse prognosis in renal cell carcinoma with venous tumor thrombus.6
369330412023High TOX expression on CD8(+) T cells in pure red cell aplasia.0
369692162023TOX regulates T lymphocytes differentiation and its function in tumor.2
379619482023Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in Acute Leukemia.0
336089842022Increased TOX expression concurrent with PD-1, Tim-3, and CD244 in T cells from patients with non-Hodgkin lymphoma.12

Citation

Dessen P

TOX (thymocyte selection associated high mobility group box)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47116/tox-(thymocyte-selection-associated-high-mobility-group-box)