Identity
HGNC
LOCATION
12p12.3
LOCUSID
ALIAS
NYD-SP27,PLC-zeta-1,PLCzeta,SPGF17
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 89869
MIM: 608075
HGNC: 19218
Ensembl: ENSG00000139151
Variants:
dbSNP: 89869
ClinVar: 89869
TCGA: ENSG00000139151
COSMIC: PLCZ1
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA26097 | CASR | Gene | Pathway | associated | |||
| PA33759 | PRKCA | Gene | Pathway | associated | |||
| PA33761 | PRKCB | Gene | Pathway | associated | |||
| PA33766 | PRKCG | Gene | Pathway | associated | |||
| PA33767 | PRKCH | Gene | Pathway | associated | |||
| PA33768 | PRKCI | Gene | Pathway | associated | |||
| PA33771 | PRKD1 | Gene | Pathway | associated | |||
| PA33775 | PRKCZ | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38279344 | 2024 | Phospholipase C Zeta in Human Spermatozoa: A Systematic Review on Current Development and Clinical Application. | 0 |
| 38445955 | 2024 | Novel PLCZ1 mutation caused polyspermy during in vitro fertilization. | 0 |
| 38279344 | 2024 | Phospholipase C Zeta in Human Spermatozoa: A Systematic Review on Current Development and Clinical Application. | 0 |
| 38445955 | 2024 | Novel PLCZ1 mutation caused polyspermy during in vitro fertilization. | 0 |
| 36593593 | 2023 | Novel variants in ACTL7A and PLCZ1 are associated with male infertility and total fertilization failure. | 4 |
| 36593593 | 2023 | Novel variants in ACTL7A and PLCZ1 are associated with male infertility and total fertilization failure. | 4 |
| 34893574 | 2022 | Antigen unmasking does not improve the visualization of phospholipase C zeta in human spermatozoa. | 4 |
| 34893574 | 2022 | Antigen unmasking does not improve the visualization of phospholipase C zeta in human spermatozoa. | 4 |
| 33626338 | 2021 | Homozygous pathogenic variants in ACTL9 cause fertilization failure and male infertility in humans and mice. | 20 |
| 33626338 | 2021 | Homozygous pathogenic variants in ACTL9 cause fertilization failure and male infertility in humans and mice. | 20 |
| 31463947 | 2020 | Novel homozygous variations in PLCZ1 lead to poor or failed fertilization characterized by abnormal localization patterns of PLCζ in sperm. | 24 |
| 31736165 | 2020 | The alteration of PLCζ protein expression in unexplained infertile and asthenoteratozoospermic patients: A potential effect on sperm fertilization ability. | 10 |
| 31953539 | 2020 | The identification of novel mutations in PLCZ1 responsible for human fertilization failure and a therapeutic intervention by artificial oocyte activation. | 16 |
| 32048714 | 2020 | Novel mutations in PLCZ1 cause male infertility due to fertilization failure or poor fertilization. | 19 |
| 32142120 | 2020 | A novel homozygous mutation of phospholipase C zeta leading to defective human oocyte activation and fertilization failure. | 16 |
Citation
Dessen P
PLCZ1 (phospholipase C zeta 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47130/plcz1-(phospholipase-c-zeta-1)
