PPP1R7 (protein phosphatase 1 regulatory subunit 7)

2007-04-01  

Identity

HGNC
PPP1R7
LOCATION
2q37.3
LOCUSID
5510
ALIAS
SDS22
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5510
MIM: 602877
HGNC: 9295
Ensembl: ENSG00000115685

Variants:

dbSNP: 5510
ClinVar: 5510
TCGA: ENSG00000115685
COSMIC: PPP1R7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115685ENST00000234038Q15435
ENSG00000115685ENST00000234038A0A140VK83
ENSG00000115685ENST00000272983Q15435
ENSG00000115685ENST00000401987Q15435
ENSG00000115685ENST00000402734Q15435
ENSG00000115685ENST00000404405B5MBZ8
ENSG00000115685ENST00000406106Q15435
ENSG00000115685ENST00000407025Q15435
ENSG00000115685ENST00000407025A0A140VK83
ENSG00000115685ENST00000415769H7C3Q5
ENSG00000115685ENST00000423280C9J177
ENSG00000115685ENST00000427172H7C118
ENSG00000115685ENST00000438799C9JD73
ENSG00000115685ENST00000439916C9JRC4
ENSG00000115685ENST00000450367H7C003

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
305006802019Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway.7
306618522019Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1.8
305006802019Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway.7
306618522019Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1.8
296697862018Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.10
296697862018Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.10
275576602016Phosphorylation of PP1 Regulator Sds22 by PLK1 Ensures Accurate Chromosome Segregation.8
276856282016The Fra-1-miR-134-SDS22 feedback loop amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells.16
275576602016Phosphorylation of PP1 Regulator Sds22 by PLK1 Ensures Accurate Chromosome Segregation.8
276856282016The Fra-1-miR-134-SDS22 feedback loop amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells.16
261683972015Kinetochore-localized PP1-Sds22 couples chromosome segregation to polar relaxation.64
261683972015Kinetochore-localized PP1-Sds22 couples chromosome segregation to polar relaxation.64
252983952014Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1.19
252983952014Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1.19
228017822012Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores.45

Citation

Dessen P

PPP1R7 (protein phosphatase 1 regulatory subunit 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47131/ppp1r7-(protein-phosphatase-1-regulatory-subunit-7)