Identity
HGNC
LOCATION
9p21.1
LOCUSID
ALIAS
RIG-I,RIG1,RIGI,RLR-1,SGMRT2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23586
MIM: 609631
HGNC: 19102
Ensembl: ENSG00000107201
Variants:
dbSNP: 23586
ClinVar: 23586
TCGA: ENSG00000107201
COSMIC: DDX58
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000107201 | ENST00000379868 | A2A376 |
| ENSG00000107201 | ENST00000379883 | O95786 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164722208 | MAVS | Gene | Pathway | associated | 26111151 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38301909 | 2024 | NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway. | 0 |
| 38466944 | 2024 | IFI16 Positively Regulates RIG-I-Mediated Type I Interferon Production in a STING-Independent Manner. | 0 |
| 38663254 | 2024 | Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation. | 0 |
| 38673764 | 2024 | Activation of the RIG-I/MAVS Signaling Pathway during Human Adenovirus Type 3 Infection Impairs the Pro-Inflammatory Response Induced by Secondary Infection with Staphylococcus aureus. | 0 |
| 38752537 | 2024 | DDX58 variant triggers IFN-β-induced autophagy in trabecular meshwork and influences intraocular pressure. | 0 |
| 38301909 | 2024 | NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway. | 0 |
| 38466944 | 2024 | IFI16 Positively Regulates RIG-I-Mediated Type I Interferon Production in a STING-Independent Manner. | 0 |
| 38663254 | 2024 | Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation. | 0 |
| 38673764 | 2024 | Activation of the RIG-I/MAVS Signaling Pathway during Human Adenovirus Type 3 Infection Impairs the Pro-Inflammatory Response Induced by Secondary Infection with Staphylococcus aureus. | 0 |
| 38752537 | 2024 | DDX58 variant triggers IFN-β-induced autophagy in trabecular meshwork and influences intraocular pressure. | 0 |
| 36261300 | 2023 | Clinical Implications of a New DDX58 Pathogenic Variant That Causes Lupus Nephritis due to RIG-I Hyperactivation. | 10 |
| 36309611 | 2023 | Retinoic acid-inducible gene 1 (RIG-1) and IFN-β promoter stimulator-1 (IPS-1) significantly down-regulated in the severe coronavirus disease 2019 (COVID-19). | 1 |
| 36515138 | 2023 | K63-linked polyubiquitination of LGP2 by Riplet regulates RIG-I-dependent innate immune response. | 1 |
| 36535188 | 2023 | The differential expression of toll like receptors and RIG-1 in the placenta of neonates with in utero infections. | 0 |
| 36634551 | 2023 | The differential expression of toll like receptors and RIG-1 correlates to the severity of infectious diseases. | 1 |
Citation
Dessen P
DDX58 (DExD/H-box helicase 58)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47150/ddx58-(dexd-h-box-helicase-58)
