RNF19A (ring finger protein 19A, RBR E3 ubiquitin protein ligase)

2007-04-01  

Identity

HGNC
LOCATION
8q22.2
LOCUSID
ALIAS
RNF19
FUSION GENES

Other Information

Locus ID:

NCBI: 25897
MIM: 607119
HGNC: 13432
Ensembl: ENSG00000034677

Variants:

dbSNP: 25897
ClinVar: 25897
TCGA: ENSG00000034677
COSMIC: RNF19A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000034677ENST00000341084Q9NV58
ENSG00000034677ENST00000432381A3KCU8
ENSG00000034677ENST00000517584A0A0C4DGD6
ENSG00000034677ENST00000519449Q9NV58
ENSG00000034677ENST00000519527E7ETB2
ENSG00000034677ENST00000522369E7EQ63
ENSG00000034677ENST00000523167E7EQV8
ENSG00000034677ENST00000523481E5RJH6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
366234452023CRISPR screening reveals gleason score and castration resistance related oncodriver ring finger protein 19 A (RNF19A) in prostate cancer.3
373266872023LncRNA KCNQ10T1 shuttled by bone marrow mesenchymal stem cell-derived exosome inhibits sepsis via regulation of miR-154-3p/RNF19A axis.3
366234452023CRISPR screening reveals gleason score and castration resistance related oncodriver ring finger protein 19 A (RNF19A) in prostate cancer.3
373266872023LncRNA KCNQ10T1 shuttled by bone marrow mesenchymal stem cell-derived exosome inhibits sepsis via regulation of miR-154-3p/RNF19A axis.3
341848142021Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth.7
347897682021RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination.5
341848142021Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth.7
347897682021RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination.5
224937212012Averaged differential expression for the discovery of biomarkers in the blood of patients with prostate cancer.5
224937212012Averaged differential expression for the discovery of biomarkers in the blood of patients with prostate cancer.5
187218672008Cooperative exonization of MaLR and AluJo elements contributed an alternative promoter and novel splice variants of RNF19.6
187218672008Cooperative exonization of MaLR and AluJo elements contributed an alternative promoter and novel splice variants of RNF19.6
171575132007Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity.13
171575132007Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity.13
150303902004Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis.11

Citation

Dessen P

RNF19A (ring finger protein 19A, RBR E3 ubiquitin protein ligase)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47168/rnf19a-(ring-finger-protein-19a-rbr-e3-ubiquitin-protein-ligase)