UBR4 (ubiquitin protein ligase E3 component n-recognin 4)

2007-04-01  

Identity

HGNC
LOCATION
1p36.13
LOCUSID
ALIAS
RBAF600,ZUBR1,p600
FUSION GENES

Other Information

Locus ID:

NCBI: 23352
MIM: 609890
HGNC: 30313
Ensembl: ENSG00000127481

Variants:

dbSNP: 23352
ClinVar: 23352
TCGA: ENSG00000127481
COSMIC: UBR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127481ENST00000375218Q5T4S7
ENSG00000127481ENST00000375224X6R960
ENSG00000127481ENST00000375225Q5TBN9
ENSG00000127481ENST00000375254Q5T4S7
ENSG00000127481ENST00000417040A0A0A0MSW0
ENSG00000127481ENST00000425413X6RE05

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
160617922005Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600.84
160617922005Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600.84
235552652013Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling.82
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
162148862005p600, a unique protein required for membrane morphogenesis and cell survival.31
267921782016The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.20
239826922014A novel locus for episodic ataxia:UBR4 the likely candidate.18
254246452015p600/UBR4 in the central nervous system.11
255824402015KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.10
290620942017Genetic Variants Associated with Episodic Ataxia in Korea.9

Citation

Dessen P

UBR4 (ubiquitin protein ligase E3 component n-recognin 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47181/ubr4-(ubiquitin-protein-ligase-e3-component-n-recognin-4)