UBR4 (ubiquitin protein ligase E3 component n-recognin 4)

2007-04-01   Dessen P  

Identity

HGNC
UBR4
LOCATION
1p36.13
LOCUSID
23352
ALIAS
RBAF600,ZUBR1,p600
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23352
MIM: 609890
HGNC: 30313
Ensembl: ENSG00000127481

Variants:

dbSNP: 23352
ClinVar: 23352
TCGA: ENSG00000127481
COSMIC: UBR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127481ENST00000375218Q5T4S7
ENSG00000127481ENST00000375224X6R960
ENSG00000127481ENST00000375225Q5TBN9
ENSG00000127481ENST00000375254Q5T4S7
ENSG00000127481ENST00000417040A0A0A0MSW0
ENSG00000127481ENST00000425413X6RE05

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
350328652022Rift Valley fever virus Gn V5-epitope tagged virus enables identification of UBR4 as a Gn interacting protein that facilitates Rift Valley fever virus production.2
350328652022Rift Valley fever virus Gn V5-epitope tagged virus enables identification of UBR4 as a Gn interacting protein that facilitates Rift Valley fever virus production.2
321707302020A new 1p36.13-1p36.12 microdeletion syndrome characterized by learning disability, behavioral abnormalities, and ptosis.4
325589062020UBR E3 ligases and the PDIA3 protease control degradation of unfolded antibody heavy chain by ERAD.3
321707302020A new 1p36.13-1p36.12 microdeletion syndrome characterized by learning disability, behavioral abnormalities, and ptosis.4
325589062020UBR E3 ligases and the PDIA3 protease control degradation of unfolded antibody heavy chain by ERAD.3
301115822018The N-recognin UBR4 of the N-end rule pathway is targeted to and required for the biogenesis of the early endosome.6
301115822018The N-recognin UBR4 of the N-end rule pathway is targeted to and required for the biogenesis of the early endosome.6
290620942017Genetic Variants Associated with Episodic Ataxia in Korea.36
290620942017Genetic Variants Associated with Episodic Ataxia in Korea.36
267921782016The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.28
267921782016The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.28
254246452015p600/UBR4 in the central nervous system.16
255824402015KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.19
254246452015p600/UBR4 in the central nervous system.16

Citation

Dessen P

UBR4 (ubiquitin protein ligase E3 component n-recognin 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47181/ubr4-(ubiquitin-protein-ligase-e3-component-n-recognin-4)