BATF (basic leucine zipper ATF-like transcription factor)

2007-04-01  

Identity

HGNC
BATF
LOCATION
14q24.3
LOCUSID
10538
ALIAS
B-ATF,BATF1,SFA-2,SFA2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10538
MIM: 612476
HGNC: 958
Ensembl: ENSG00000156127

Variants:

dbSNP: 10538
ClinVar: 10538
TCGA: ENSG00000156127
COSMIC: BATF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156127ENST00000286639Q16520
ENSG00000156127ENST00000555504G3V266

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA283MAPK8GenePathwayassociated23922006
PA30621MAPK14GenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
366407522023BATF reprograms the tumor immune status.0
373789492023Relative Expression of BATF and CD112 in PBMC of Patients with Chronic Lymphocytic Leukemia.0
377135082023Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells.6
366407522023BATF reprograms the tumor immune status.0
373789492023Relative Expression of BATF and CD112 in PBMC of Patients with Chronic Lymphocytic Leukemia.0
377135082023Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells.6
351026122022Supervised machine learning algorithm identified KRT20, BATF and TP63 as biologically relevant biomarkers for bladder biopsy specimens from interstitial cystitis/bladder pain syndrome patients.1
355114842022A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation.9
362063532022BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors.21
362407772022Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells.27
351026122022Supervised machine learning algorithm identified KRT20, BATF and TP63 as biologically relevant biomarkers for bladder biopsy specimens from interstitial cystitis/bladder pain syndrome patients.1
355114842022A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation.9
362063532022BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors.21
362407772022Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells.27
327336202020Prognostic Value of DNA Methylation-Driven Genes in Clear Cell Renal Cell Carcinoma: A Study Based on Methylation and Transcriptome Analyses.4

Citation

Dessen P

BATF (basic leucine zipper ATF-like transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47196/batf-(basic-leucine-zipper-atf-like-transcription-factor)