HECTD3 (HECT domain E3 ubiquitin protein ligase 3)

2007-04-01  

Identity

HGNC
HECTD3
LOCATION
1p34.1
LOCUSID
79654
ALIAS
-

Other Information

Locus ID:

NCBI: 79654
MIM: 618638
HGNC: 26117
Ensembl: ENSG00000126107

Variants:

dbSNP: 79654
ClinVar: 79654
TCGA: ENSG00000126107
COSMIC: HECTD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126107ENST00000372168Q5T447
ENSG00000126107ENST00000372172Q5T447

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374220582023E3 ubiquitin ligase HECTD3 is a tumor suppressor and mediates the polyubiquitination of SLC7A11 to promote ferroptosis in colon cancer.5
374220582023E3 ubiquitin ligase HECTD3 is a tumor suppressor and mediates the polyubiquitination of SLC7A11 to promote ferroptosis in colon cancer.5
360885092022HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.3
360885092022HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.3
316374492020The role of E3 ubiquitin ligase HECTD3 in cancer and beyond.16
316374492020The role of E3 ubiquitin ligase HECTD3 in cancer and beyond.16
286369402017HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.15
286369402017HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.15
233588722013The HECTD3 E3 ubiquitin ligase suppresses cisplatin-induced apoptosis via stabilizing MALT1.19
233588722013The HECTD3 E3 ubiquitin ligase suppresses cisplatin-induced apoptosis via stabilizing MALT1.19
181946652008The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara.14
181946652008The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara.14

Citation

Dessen P

HECTD3 (HECT domain E3 ubiquitin protein ligase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47202/hectd3-(hect-domain-e3-ubiquitin-protein-ligase-3)