PPP1R12A (protein phosphatase 1 regulatory subunit 12A)

2007-04-01  

Identity

HGNC
PPP1R12A
LOCATION
12q21.2
LOCUSID
4659
ALIAS
GUBS,M130,MBS,MYPT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4659
MIM: 602021
HGNC: 7618
Ensembl: ENSG00000058272

Variants:

dbSNP: 4659
ClinVar: 4659
TCGA: ENSG00000058272
COSMIC: PPP1R12A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000058272ENST00000261207O14974
ENSG00000058272ENST00000437004O14974
ENSG00000058272ENST00000450142O14974
ENSG00000058272ENST00000546369O14974
ENSG00000058272ENST00000546762H0YIS3
ENSG00000058272ENST00000547131H0YIS4
ENSG00000058272ENST00000547330F8VZN8
ENSG00000058272ENST00000548318F8VW28
ENSG00000058272ENST00000550107O14974
ENSG00000058272ENST00000550299H0YIM2
ENSG00000058272ENST00000550510H0YHL8
ENSG00000058272ENST00000550903H0YIL7
ENSG00000058272ENST00000553081H0YHI8
ENSG00000058272ENST00000634739A0A0U1RQZ1
ENSG00000058272ENST00000650220A0A3B3ISH4

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Regulation of actin cytoskeletonKEGGko04810
Focal adhesionKEGGhsa04510
Regulation of actin cytoskeletonKEGGhsa04810
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ROCKsREACTOMER-HSA-5627117
RHO GTPases activate PAKsREACTOMER-HSA-5627123
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386155532024Differential expression of PPP1R12A transcripts, including those harbouring alternatively spliced micro-exons, in placentae from complicated pregnancies.0
386155532024Differential expression of PPP1R12A transcripts, including those harbouring alternatively spliced micro-exons, in placentae from complicated pregnancies.0
379571902023PPP1R12A is a recycling endosomal phosphatase that facilitates YAP activation.0
379571902023PPP1R12A is a recycling endosomal phosphatase that facilitates YAP activation.0
351070222022Tissue-specific expression of myosin phosphatase subunits and isoforms in smooth muscle of mice and humans.2
359541602022Complex Transcriptional Profiles of the PPP1R12A Gene in Cells of the Circulatory System as Revealed by In Silico Analysis and Reverse Transcription PCR.0
361064112022MYPT1 inhibits the metastasis of renal clear cell carcinoma via the MAPK8/N-cadherin pathway.0
363315102022Persistent Müllerian duct syndrome associated with genetic defects in the regulatory subunit of myosin phosphatase.1
351070222022Tissue-specific expression of myosin phosphatase subunits and isoforms in smooth muscle of mice and humans.2
359541602022Complex Transcriptional Profiles of the PPP1R12A Gene in Cells of the Circulatory System as Revealed by In Silico Analysis and Reverse Transcription PCR.0
361064112022MYPT1 inhibits the metastasis of renal clear cell carcinoma via the MAPK8/N-cadherin pathway.0
363315102022Persistent Müllerian duct syndrome associated with genetic defects in the regulatory subunit of myosin phosphatase.1
334595692021Haplotype-based, case-control study of myosin phosphatase target subunit 1 (PPP1R12A) gene and hypertensive disorders of pregnancy.2
335959452021CircPPP1R12A promotes the progression of colon cancer through regulating CTNNB1 via sponging miR-375.5
337840002021Novel circular RNA circSOBP governs amoeboid migration through the regulation of the miR-141-3p/MYPT1/p-MLC2 axis in prostate cancer.23

Citation

Dessen P

PPP1R12A (protein phosphatase 1 regulatory subunit 12A)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47222/ppp1r12a-(protein-phosphatase-1-regulatory-subunit-12a)