PIP5K1C (phosphatidylinositol-4-phosphate 5-kinase type 1 gamma)

2007-04-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
LCCS3,PIP5K-GAMMA,PIP5K1-gamma,PIP5Kgamma
FUSION GENES

Other Information

Locus ID:

NCBI: 23396
MIM: 606102
HGNC: 8996
Ensembl: ENSG00000186111

Variants:

dbSNP: 23396
ClinVar: 23396
TCGA: ENSG00000186111
COSMIC: PIP5K1C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186111ENST00000335312O60331
ENSG00000186111ENST00000537021O60331
ENSG00000186111ENST00000539785O60331
ENSG00000186111ENST00000589578O60331

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Phosphatidylinositol signaling systemKEGGko04070
Focal adhesionKEGGko04510
Regulation of actin cytoskeletonKEGGko04810
Inositol phosphate metabolismKEGGhsa00562
Phosphatidylinositol signaling systemKEGGhsa04070
Focal adhesionKEGGhsa04510
Regulation of actin cytoskeletonKEGGhsa04810
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Metabolic pathwaysKEGGhsa01100
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGhsa_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGM00130
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
PIP3 activates AKT signalingREACTOMER-HSA-1257604
Negative regulation of the PI3K/AKT networkREACTOMER-HSA-199418
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GAB1 signalosomeREACTOMER-HSA-180292
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PI3K/AKT activationREACTOMER-HSA-198203
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by SCF-KITREACTOMER-HSA-1433557
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the plasma membraneREACTOMER-HSA-1660499
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionREACTOMER-HSA-399955
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingREACTOMER-HSA-6811558
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD
PA448073ethanolChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
124222202002Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions.172
124222192002Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin.168
95358511998Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family.93
172618502007Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin.77
168803962006Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes.58
156113302004Critical role of PIP5KI{gamma}87 in InsP3-mediated Ca(2+) signaling.49
167074882006Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis.48
96285811998Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.44
176359372007Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration.40
195488802009Two novel phosphatidylinositol-4-phosphate 5-kinase type Igamma splice variants expressed in human cells display distinctive cellular targeting.37

Citation

Dessen P

PIP5K1C (phosphatidylinositol-4-phosphate 5-kinase type 1 gamma)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47224/pip5k1c-(phosphatidylinositol-4-phosphate-5-kinase-type-1-gamma)