FBXO43 (F-box protein 43)

2007-04-01  

Identity

HGNC
FBXO43
LOCATION
8q22.2
LOCUSID
286151
ALIAS
EMI2,ERP1,FBX43

Other Information

Locus ID:

NCBI: 286151
MIM: 609110
HGNC: 28521
Ensembl: ENSG00000156509

Variants:

dbSNP: 286151
ClinVar: 286151
TCGA: ENSG00000156509
COSMIC: FBXO43

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156509ENST00000428847Q4G163
ENSG00000156509ENST00000517806E5RHI5

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
367104132023Association between F-box-only protein 43 overexpression and hepatocellular carcinoma pathogenesis and prognosis.4
372507032023Clinical significance of FBXO43 in hepatocellular carcinoma and its impact on tumor cell proliferation, migration and invasion.2
367104132023Association between F-box-only protein 43 overexpression and hepatocellular carcinoma pathogenesis and prognosis.4
372507032023Clinical significance of FBXO43 in hepatocellular carcinoma and its impact on tumor cell proliferation, migration and invasion.2
345957502022A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia.3
345957502022A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia.3
340528502021FBXO43 variants in patients with female infertility characterized by early embryonic arrest.12
346454832021Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA.7
340528502021FBXO43 variants in patients with female infertility characterized by early embryonic arrest.12
346454832021Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA.7
322538182020EMI2 expression as a poor prognostic factor in patients with breast cancer.11
322538182020EMI2 expression as a poor prognostic factor in patients with breast cancer.11
308782522019A novel homozygous FBXO43 mutation associated with male infertility and teratozoospermia in a consanguineous Chinese family.11
308782522019A novel homozygous FBXO43 mutation associated with male infertility and teratozoospermia in a consanguineous Chinese family.11
185507952008Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.15

Citation

Dessen P

FBXO43 (F-box protein 43)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47237/fbxo43-(f-box-protein-43)