Identity
HGNC
LOCATION
16p13.2
LOCUSID
ALIAS
EPND,FESD,GluN2A,LKS,NMDAR2A,NR2A
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2903
MIM: 138253
HGNC: 4585
Ensembl: ENSG00000183454
Variants:
dbSNP: 2903
ClinVar: 2903
TCGA: ENSG00000183454
COSMIC: GRIN2A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA449841 | haloperidol | Chemical | MultilinkAnnotation | associated | 27023437 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38214768 | 2024 | Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids. | 0 |
| 38307912 | 2024 | Differential functional consequences of GRIN2A mutations associated with schizophrenia and neurodevelopmental disorders. | 0 |
| 38319733 | 2024 | METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2. | 1 |
| 38731978 | 2024 | Dual Role of NMDAR Containing NR2A and NR2B Subunits in Alzheimer's Disease. | 0 |
| 38214768 | 2024 | Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids. | 0 |
| 38307912 | 2024 | Differential functional consequences of GRIN2A mutations associated with schizophrenia and neurodevelopmental disorders. | 0 |
| 38319733 | 2024 | METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2. | 1 |
| 38731978 | 2024 | Dual Role of NMDAR Containing NR2A and NR2B Subunits in Alzheimer's Disease. | 0 |
| 36516565 | 2023 | GRIN2A-related epilepsy and speech disorders: A comprehensive overview with a focus on the role of precision therapeutics. | 1 |
| 37000222 | 2023 | Functional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening. | 1 |
| 37107537 | 2023 | Children with Early-Onset Psychosis Have Increased Burden of Rare GRIN2A Variants. | 1 |
| 37736757 | 2023 | GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia. | 4 |
| 36516565 | 2023 | GRIN2A-related epilepsy and speech disorders: A comprehensive overview with a focus on the role of precision therapeutics. | 1 |
| 37000222 | 2023 | Functional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening. | 1 |
| 37107537 | 2023 | Children with Early-Onset Psychosis Have Increased Burden of Rare GRIN2A Variants. | 1 |
Citation
Dessen P
GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47251/grin2a-(glutamate-ionotropic-receptor-nmda-type-subunit-2a)
