DLL3 (delta like canonical Notch ligand 3)

2007-04-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
SCDO1
FUSION GENES

Other Information

Locus ID:

NCBI: 10683
MIM: 602768
HGNC: 2909
Ensembl: ENSG00000090932

Variants:

dbSNP: 10683
ClinVar: 10683
TCGA: ENSG00000090932
COSMIC: DLL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090932ENST00000205143Q9NYJ7
ENSG00000090932ENST00000596614M0R177

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Notch signaling pathwayKEGGko04330
Notch signaling pathwayKEGGhsa04330
Notch signalingKEGGhsa_M00682
Notch signalingKEGGM00682
Endocrine resistanceKEGGko01522
Endocrine resistanceKEGGhsa01522
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658

References

Pubmed IDYearTitleCitations
119232142002Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm.56
186766132008The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity.37
127463942003Novel mutations in DLL3, a somitogenesis gene encoding a ligand for the Notch signalling pathway, cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis.24
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
292902512018Prevalence of Delta-like protein 3 expression in patients with small cell lung cancer.14
308944992019Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer.13
233379762013Delta-like 3 is silenced by methylation and induces apoptosis in human hepatocellular carcinoma.12
303273112019Transcriptomic and Protein Analysis of Small-cell Bladder Cancer (SCBC) Identifies Prognostic Biomarkers and DLL3 as a Relevant Therapeutic Target.10
157172032005Molecular analysis of congenital scoliosis: a candidate gene approach.9
280075952017The Notch ligand delta-like 3 promotes tumor growth and inhibits Notch signaling in lung cancer cells in mice.8

Citation

Dessen P

DLL3 (delta like canonical Notch ligand 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47257/dll3-(delta-like-canonical-notch-ligand-3)