PPP3CC (protein phosphatase 3 catalytic subunit gamma)

2007-04-01  

Identity

HGNC
PPP3CC
LOCATION
8p21.3
LOCUSID
5533
ALIAS
CALNA3,CNA3,PP2Bgamma
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5533
MIM: 114107
HGNC: 9316
Ensembl: ENSG00000120910

Variants:

dbSNP: 5533
ClinVar: 5533
TCGA: ENSG00000120910
COSMIC: PPP3CC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120910ENST00000240139P48454
ENSG00000120910ENST00000289963P48454
ENSG00000120910ENST00000397775P48454
ENSG00000120910ENST00000518852G3V111
ENSG00000120910ENST00000521651H0YB04
ENSG00000120910ENST00000522000H0YB02
ENSG00000120910ENST00000522034H0YC26
ENSG00000120910ENST00000523620E5RJH4

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Calcium signaling pathwayKEGGko04020
Wnt signaling pathwayKEGGko04310
Axon guidanceKEGGko04360
VEGF signaling pathwayKEGGko04370
Natural killer cell mediated cytotoxicityKEGGko04650
T cell receptor signaling pathwayKEGGko04660
B cell receptor signaling pathwayKEGGko04662
Long-term potentiationKEGGko04720
Alzheimer's diseaseKEGGko05010
Amyotrophic lateral sclerosis (ALS)KEGGko05014
MAPK signaling pathwayKEGGhsa04010
Calcium signaling pathwayKEGGhsa04020
Wnt signaling pathwayKEGGhsa04310
Axon guidanceKEGGhsa04360
VEGF signaling pathwayKEGGhsa04370
Natural killer cell mediated cytotoxicityKEGGhsa04650
T cell receptor signaling pathwayKEGGhsa04660
B cell receptor signaling pathwayKEGGhsa04662
Long-term potentiationKEGGhsa04720
Alzheimer's diseaseKEGGhsa05010
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
Opioid SignallingREACTOMER-HSA-111885
DARPP-32 eventsREACTOMER-HSA-180024
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of BAD and translocation to mitochondriaREACTOMER-HSA-111447
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA248NFKB1GenePathwayassociated23922006
PA296RELAGenePathwayassociated23922006
PA31582NFATC1GenePathwayassociated23922006
PA31583NFATC2GenePathwayassociated23922006
PA31584NFATC4GenePathwayassociated23922006
PA31600NFKB2GenePathwayassociated23922006
PA34321RELGenePathwayassociated23922006
PA34322RELBGenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
376609942024LINC-PINT suppresses breast cancer cell proliferation and migration via MEIS2/PPP3CC/NF-κB pathway by sponging miR-576-5p.0
376609942024LINC-PINT suppresses breast cancer cell proliferation and migration via MEIS2/PPP3CC/NF-κB pathway by sponging miR-576-5p.0
333931092021Calcineurin A gamma and NFATc3/SRPX2 axis contribute to human embryonic stem cell differentiation.6
345733822021Calcineurin Gamma Catalytic Subunit PPP3CC Inhibition by miR-200c-3p Affects Apoptosis in Epithelial Ovarian Cancer.4
333931092021Calcineurin A gamma and NFATc3/SRPX2 axis contribute to human embryonic stem cell differentiation.6
345733822021Calcineurin Gamma Catalytic Subunit PPP3CC Inhibition by miR-200c-3p Affects Apoptosis in Epithelial Ovarian Cancer.4
292753642018Genetic Variations in the 3'-untranslated Regions of Genes Involved in the Cell Cycle and Apoptosis Pathways Affect Bladder Cancer Risk.3
292940302018Repression of the expression of PPP3CC by ZEB1 confers activation of NF-κB and contributes to invasion and growth in glioma cells.10
292753642018Genetic Variations in the 3'-untranslated Regions of Genes Involved in the Cell Cycle and Apoptosis Pathways Affect Bladder Cancer Risk.3
292940302018Repression of the expression of PPP3CC by ZEB1 confers activation of NF-κB and contributes to invasion and growth in glioma cells.10
272258802017Variation in PPP3CC Genotype Is Associated with Long-Term Recovery after Severe Brain Injury.6
272258802017Variation in PPP3CC Genotype Is Associated with Long-Term Recovery after Severe Brain Injury.6
266278352016Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis.14
266278352016Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis.14
247096912014PPP3CC gene: a putative modulator of antidepressant response through the B-cell receptor signaling pathway.13

Citation

Dessen P

PPP3CC (protein phosphatase 3 catalytic subunit gamma)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47268/ppp3cc-(protein-phosphatase-3-catalytic-subunit-gamma)