RORC (RAR related orphan receptor C)

2007-04-01  

Identity

HGNC
RORC
LOCATION
1q21.3
LOCUSID
6097
ALIAS
IMD42,NR1F3,RORG,RZR-GAMMA,RZRG,TOR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6097
MIM: 602943
HGNC: 10260
Ensembl: ENSG00000143365

Variants:

dbSNP: 6097
ClinVar: 6097
TCGA: ENSG00000143365
COSMIC: RORC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143365ENST00000318247P51449
ENSG00000143365ENST00000318247Q6I9R9
ENSG00000143365ENST00000356728P51449
ENSG00000143365ENST00000356728F1D8P6
ENSG00000143365ENST00000638901A0A1W2PRM4
ENSG00000143365ENST00000651814A0A494C0S6
ENSG00000143365ENST00000651893A0A494C174
ENSG00000143365ENST00000652040A0A494C0H2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Circadian rhythmKEGGko04710
Circadian rhythmKEGGhsa04710
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

References

Pubmed IDYearTitleCitations
387226772024Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORγt.1
387226772024Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORγt.1
329601522021Possible Role of the RORC Gene in Primary and Secondary Lymphedema: Review of the Literature and Genetic Study of Two Rare Causative Variants.5
330686742021The expression analyses of RMRP, DDX5, and RORC in RRMS patients treated with different drugs versus naïve patients and healthy controls.7
335069372021Correlations of Helicobacter pylori with liver function, inflammatory factors and serum levels of FoxP3 and RORγt in patients with hepatitis B cirrhosis.2
335363422021Cooperativity between the orthosteric and allosteric ligand binding sites of RORγt.16
336330272021Increased Expression of IL-17A and IL-17F Is Correlated With RUNX1 and RORγT in Pediatric Patients With Primary Immune Thrombocytopenia.2
337716872021Associations of TNFA, IL17A, and RORC mRNA expression levels in peripheral blood leukocytes with obesity-related asthma in adolescents.5
341838382021Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child.51
342522052021RORC gene polymorphism is associated with acute kidney injury following cardiac surgery.1
345473292021Conformational Changes of RORγ During Response Element Recognition and Coregulator Engagement.1
346737992021Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells.0
348193672021Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth.12
329601522021Possible Role of the RORC Gene in Primary and Secondary Lymphedema: Review of the Literature and Genetic Study of Two Rare Causative Variants.5
330686742021The expression analyses of RMRP, DDX5, and RORC in RRMS patients treated with different drugs versus naïve patients and healthy controls.7

Citation

Dessen P

RORC (RAR related orphan receptor C)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47292/js/lib/welcome