FBXO46 (F-box protein 46)

2007-04-01  

Identity

HGNC
FBXO46
LOCATION
19q13.32
LOCUSID
23403
ALIAS
20D7-FC4,FBXO34L,Fbx46
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23403
MIM: 609117
HGNC: 25069
Ensembl: ENSG00000177051

Variants:

dbSNP: 23403
ClinVar: 23403
TCGA: ENSG00000177051
COSMIC: FBXO46

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177051ENST00000317683Q6PJ61
ENSG00000177051ENST00000586899K7ERN4
ENSG00000177051ENST00000591686K7EKF1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
301710692018The SCF(FBXO46) ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence.3
301710692018The SCF(FBXO46) ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence.3

Citation

Dessen P

FBXO46 (F-box protein 46)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47311/fbxo46-(f-box-protein-46)