PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2)

2007-04-01  

Identity

HGNC
LOCATION
1q21.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 5565
MIM: 602741
HGNC: 9379
Ensembl: ENSG00000131791

Variants:

dbSNP: 5565
ClinVar: 5565
TCGA: ENSG00000131791
COSMIC: PRKAB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131791ENST00000254101O43741

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Circadian rhythmKEGGko04710
Insulin signaling pathwayKEGGko04910
Adipocytokine signaling pathwayKEGGko04920
Tight junctionKEGGhsa04530
Circadian rhythmKEGGhsa04710
Insulin signaling pathwayKEGGhsa04910
Adipocytokine signaling pathwayKEGGhsa04920
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
FoxO signaling pathwayKEGGhsa04068
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Activation of PPARGC1A (PGC-1alpha) by phosphorylationREACTOMER-HSA-2151209
Signal TransductionREACTOMER-HSA-162582
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
PI3K CascadeREACTOMER-HSA-109704
PKB-mediated eventsREACTOMER-HSA-109703
mTOR signallingREACTOMER-HSA-165159
Energy dependent regulation of mTOR by LKB1-AMPKREACTOMER-HSA-380972
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Import of palmitoyl-CoA into the mitochondrial matrixREACTOMER-HSA-200425
Integration of energy metabolismREACTOMER-HSA-163685
AMPK inhibits chREBP transcriptional activation activityREACTOMER-HSA-163680
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Insulin resistanceKEGGhsa04931
Longevity regulating pathwayKEGGhsa04211
Longevity regulating pathway - multiple speciesKEGGko04213
Longevity regulating pathway - multiple speciesKEGGhsa04213
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134983031GPAMGenePathwayassociated22722338
PA142672073CRTC2GenePathwayassociated22722338
PA189HMGCRGenePathwayassociated22722338
PA24421ACACAGenePathwayassociated22722338
PA24422ACACBGenePathwayassociated22722338
PA30861MLYCDGenePathwayassociated22722338
PA335SREBF1GenePathwayassociated22722338
PA35879SLC2A4GenePathwayassociated22722338
PA36198STK11GenePathwayassociated22722338
PA37353MLXIPLGenePathwayassociated22722338
PA37935SIRT1GenePathwayassociated22722338
PA450395metforminChemicalPathwayassociated22722338
PA61ATMGenePathwayassociated22722338

References

Pubmed IDYearTitleCitations
206826872010Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
229355352012AMP-activated protein kinase regulation and biological actions in the heart.85
228979282012Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications.22
205348082010The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.19
199489752009Integrative predictive model of coronary artery calcification in atherosclerosis.13
235526912013Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activity.12
189961022009Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
223054902012Association study between variants of AMP-activated protein kinase catalytic and regulatory subunit genes with antipsychotic-induced weight gain.6

Citation

Dessen P

PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47316/prkab2-(protein-kinase-amp-activated-non-catalytic-subunit-beta-2)