DDX23 (DEAD-box helicase 23)

2007-04-01  

Identity

HGNC
DDX23
LOCATION
12q13.12
LOCUSID
9416
ALIAS
PRPF28,SNRNP100,U5-100K,U5-100KD,prp28
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9416
MIM: 612172
HGNC: 17347
Ensembl: ENSG00000174243

Variants:

dbSNP: 9416
ClinVar: 9416
TCGA: ENSG00000174243
COSMIC: DDX23

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174243ENST00000308025Q9BUQ8
ENSG00000174243ENST00000308025A0A024R0Z3
ENSG00000174243ENST00000547135Q9BUQ8
ENSG00000174243ENST00000550834H0YIL9
ENSG00000174243ENST00000551468F8W1J5
ENSG00000174243ENST00000552512F8VVA2
ENSG00000174243ENST00000552802H0YI52

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, U4/U6.U5 tri-snRNPKEGGhsa_M00354
Spliceosome, U4/U6.U5 tri-snRNPKEGGM00354
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA Splicing - Minor PathwayREACTOMER-HSA-72165

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387436212024SRSF1 interactome determined by proximity labeling reveals direct interaction with spliceosomal RNA helicase DDX23.1
387436212024SRSF1 interactome determined by proximity labeling reveals direct interaction with spliceosomal RNA helicase DDX23.1
369776682023METTL3 enhances pancreatic ductal adenocarcinoma progression and gemcitabine resistance through modifying DDX23 mRNA N6 adenosine methylation.6
369776682023METTL3 enhances pancreatic ductal adenocarcinoma progression and gemcitabine resistance through modifying DDX23 mRNA N6 adenosine methylation.6
340507072021Syndromic neurodevelopmental disorder associated with de novo variants in DDX23.6
340507072021Syndromic neurodevelopmental disorder associated with de novo variants in DDX23.6
317942452020RNA Splicing by the Spliceosome.245
317942452020RNA Splicing by the Spliceosome.245
280767792017Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation.61
284736612017DDX23-Linc00630-HDAC1 axis activates the Notch pathway to promote metastasis.8
280767792017Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation.61
284736612017DDX23-Linc00630-HDAC1 axis activates the Notch pathway to promote metastasis.8
273771542016A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity.33
273771542016A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity.33
184251422008Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome.78

Citation

Dessen P

DDX23 (DEAD-box helicase 23)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47349/ddx23-(dead-box-helicase-23)