CPN1 (carboxypeptidase N subunit 1)

2007-04-01  

Identity

HGNC
LOCATION
10q24.2
LOCUSID
ALIAS
CPN,SCPN

Other Information

Locus ID:

NCBI: 1369
MIM: 603103
HGNC: 2312
Ensembl: ENSG00000120054

Variants:

dbSNP: 1369
ClinVar: 1369
TCGA: ENSG00000120054
COSMIC: CPN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120054ENST00000370418P15169
ENSG00000120054ENST00000441382B1AP58

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876

References

Pubmed IDYearTitleCitations
189403122008Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.150
206484722010PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease.105
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
157184152005Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation.35
190107842009Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets.28
180395262007Structure and function of human plasma carboxypeptidase N, the anaphylatoxin inactivator.22
210520312011Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough.9
202009782010Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.7
230004092012Binding of carboxypeptidase N to fibrinogen and fibrin.4

Citation

Dessen P

CPN1 (carboxypeptidase N subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47373/cpn1-(carboxypeptidase-n-subunit-1)