EED (embryonic ectoderm development)

2007-04-01  

Identity

HGNC
EED
LOCATION
11q14.2
LOCUSID
8726
ALIAS
COGIS,HEED,WAIT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8726
MIM: 605984
HGNC: 3188
Ensembl: ENSG00000074266

Variants:

dbSNP: 8726
ClinVar: 8726
TCGA: ENSG00000074266
COSMIC: EED

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074266ENST00000263360O75530
ENSG00000074266ENST00000327320O75530
ENSG00000074266ENST00000351625O75530
ENSG00000074266ENST00000527888E9PMU3
ENSG00000074266ENST00000528180E9PJK2
ENSG00000074266ENST00000534595H0YEL4

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
PRC2 methylates histones and DNAREACTOMER-HSA-212300
Developmental BiologyREACTOMER-HSA-1266738
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378403852024EED related overgrowth: First report of multiple members in a single family.1
378403852024EED related overgrowth: First report of multiple members in a single family.1
356362602022The PRC2 molecule EED is a target of epigenetic therapy for neuroblastoma.1
356362602022The PRC2 molecule EED is a target of epigenetic therapy for neuroblastoma.1
338824572021Methylation of microRNA-338-5p by EED promotes METTL3-mediated translation of oncogene CDCP1 in gastric cancer.17
345443412021Embryonic Ectoderm Development (EED) as a Novel Target for Cancer Treatment.3
338824572021Methylation of microRNA-338-5p by EED promotes METTL3-mediated translation of oncogene CDCP1 in gastric cancer.17
345443412021Embryonic Ectoderm Development (EED) as a Novel Target for Cancer Treatment.3
305953802019PICOT binding to the polycomb group protein, EED, alters H3K27 methylation at the MYT1 PRC2 target gene.7
306287242019Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer.36
307934712019EED and EZH2 constitutive variants: A study to expand the Cohen-Gibson syndrome phenotype and contrast it with Weaver syndrome.12
308585062019Three additional patients with EED-associated overgrowth: potential mutation hotspots identified?5
310237852019Malignant Peripheral Nerve Sheath Tumors: From Epigenome to Bedside.32
313956082019An Allosteric PRC2 Inhibitor Targeting EED Suppresses Tumor Progression by Modulating the Immune Response.23
315275842019PICOT binding to chromatin-associated EED negatively regulates cyclin D2 expression by increasing H3K27me3 at the CCND2 gene promoter.5

Citation

Dessen P

EED (embryonic ectoderm development)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47375