GDF11 (growth differentiation factor 11)

2007-04-01  

Identity

HGNC
GDF11
LOCATION
12q13.2
LOCUSID
10220
ALIAS
BMP-11,BMP11,VHO
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10220
MIM: 603936
HGNC: 4216
Ensembl: ENSG00000135414

Variants:

dbSNP: 10220
ClinVar: 10220
TCGA: ENSG00000135414
COSMIC: GDF11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135414ENST00000257868O95390
ENSG00000135414ENST00000257868A0A024RB20
ENSG00000135414ENST00000546799H0YI30

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379059572024Oncogenic miR-106b-5p promotes cisplatin resistance in triple-negative breast cancer by targeting GDF11.0
383691812024Growth differentiation factor-11 upregulates matrix metalloproteinase 2 expression by inducing Snail in human extravillous trophoblast cells.0
379059572024Oncogenic miR-106b-5p promotes cisplatin resistance in triple-negative breast cancer by targeting GDF11.0
383691812024Growth differentiation factor-11 upregulates matrix metalloproteinase 2 expression by inducing Snail in human extravillous trophoblast cells.0
365848662023The hepatic effects of GDF11 on health and disease.1
370118722023The role of GDF11 during inflammation - An overview.2
373567382023GDF11 as a friend or an enemy in the cancer biology?1
374801232023GDF-11 downregulates placental human chorionic gonadotropin expression by activating SMAD2/3 signaling.0
377420572023Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans.3
378013472023Mutual regulation between GDF11 and TET2 prevents senescence of mesenchymal stem cells.0
381437612023The regulatory effect of growth differentiation factor 11 on different cells.1
365848662023The hepatic effects of GDF11 on health and disease.1
370118722023The role of GDF11 during inflammation - An overview.2
373567382023GDF11 as a friend or an enemy in the cancer biology?1
374801232023GDF-11 downregulates placental human chorionic gonadotropin expression by activating SMAD2/3 signaling.0

Citation

Dessen P

GDF11 (growth differentiation factor 11)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47379/gdf11-(growth-differentiation-factor-11)