ADRB1 (adrenoceptor beta 1)

2007-04-01 Affiliation

Identity

HGNC

ADRB1

LOCATION

10q25.3

LOCUSID

153

ALIAS

ADRB1R,B1AR,BETA1AR,FNSS2,RHR

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 153
MIM: 109630
HGNC: 285
Ensembl: ENSG00000043591

Variants:

dbSNP: 153
ClinVar: 153
TCGA: ENSG00000043591
COSMIC: ADRB1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000043591	ENST00000369295	P08588

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Gap junction	KEGG	ko04540
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Gap junction	KEGG	hsa04540
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Dilated cardiomyopathy	KEGG	ko05414
Dilated cardiomyopathy	KEGG	hsa05414
Salivary secretion	KEGG	ko04970
Salivary secretion	KEGG	hsa04970
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Regulation of lipolysis in adipocytes	KEGG	hsa04923
Renin secretion	KEGG	hsa04924
Renin secretion	KEGG	ko04924
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Adrenoceptors	REACTOME	R-HSA-390696
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA133822447	catecholamines	Chemical	ClinicalAnnotation	associated	PD	17541557
PA134687887	selective beta-2-adrenoreceptor agonists	Chemical	VipGene	associated		15564877, 16325050, 11753577
PA151249535	diuretics	Chemical	ClinicalAnnotation	associated	PD	22543981
PA162356187	muraglitazar	Chemical	ClinicalAnnotation	associated	PD	18794727
PA164712308	Ace Inhibitors, Plain	Chemical	ClinicalAnnotation	associated	PD	22543981
PA164712372	Angiotensin II Antagonists	Chemical	ClinicalAnnotation	associated	PD	22543981
PA164712535	Beta Blocking Agents	Chemical	ClinicalAnnotation, VipGene	associated	PD	11787477, 12709726, 12844134, 12921807, 14502278, 14534524, 15735607, 15861037, 15864115, 16153393, 16189366, 16402084, 11052857, 12709726, 12844134, 12921807, 14502278, 14534524, 15735607, 15861037, 15864115, 16815314, 17496726, 18075464, 20235788, 20352314, 20643254, 21311897, 22543981, 22617224, 28351962
PA164712541	Beta blocking agents, non-selective	Chemical	Pathway	associated
PA164712547	Beta blocking agents, selective	Chemical	Pathway	associated
PA165945764	bucindolol	Chemical	ClinicalAnnotation	associated	PD	12709726, 12844134, 12921807, 14502278, 14534524, 15735607, 15861037, 15864115, 16815314, 17496726, 18075464, 20235788, 20352314, 20643254, 21311897, 22617224
PA166129560	major adverse cardiac events (mace)	Disease	ClinicalAnnotation	associated	PD	28351962
PA166153976	rs1801252	Variant	VipGene	associated		10477438, 11052857, 11447084, 11791000, 11942593, 12034720, 12383575, 12844134, 15247626, 15312808, 15685248, 15735607, 15861037, 15864115, 15917856, 16153393, 16188498, 16189366, 16210433, 16402084, 16421173, 16815314, 16907703, 10093986
PA166153977	rs1801253	Variant	VipGene	associated		10212248, 10336842, 10477438, 10794544, 11337934, 11337935, 11447084, 11704005, 11753577, 11787477, 11942593, 12032746, 12090746, 12197595, 12374873, 12383575, 12422153, 12455717, 12525504, 12709726, 12815745, 12844134, 12921807, 14502278, 14534524, 14553962, 15055253, 15212839, 15247626, 15312808, 15342173, 15464701, 15479221, 15564877, 15685248, 15735607, 15833937, 15861037, 15864115, 15864129, 15917856, 16109321, 16122377, 16153393, 16188498, 16189366, 16210433, 16325050, 16402084, 16421173, 16815314, 16907703, 10093986
PA443319	Alzheimer Disease	Disease	VipGene	associated		15212839
PA443362	Angina Pectoris	Disease	VipGene	associated		12090746, 16189366, 16210433, 11704005
PA443364	Angina, Unstable	Disease	VipGene	associated		16189366, 12090746
PA443635	Cardiovascular Diseases	Disease	VipGene	associated		11787477, 12090746, 12709726, 12844134, 12921807, 14502278, 14534524, 14553962, 15735607, 15861037, 15864115, 15864129, 16109321, 16153393, 16189366, 16210433, 16402084, 11704005
PA443796	Coronary Artery Disease	Disease	ClinicalAnnotation, VipGene	associated	PD	12090746, 16189366, 16210433, 11704005, 17541557
PA443886	Diabetes Mellitus	Disease	ClinicalAnnotation	associated	PD	18794727
PA443994	Edema	Disease	ClinicalAnnotation	associated	PD	18794727
PA444370	Heart Failure	Disease	ClinicalAnnotation, VipGene	associated	PD	14502278, 15735607, 15861037, 15864115, 16153393, 12921807, 22543981
PA444528	Hyperlipidemias	Disease	ClinicalAnnotation	associated	PD	18794727
PA444552	Hypertension	Disease	ClinicalAnnotation, VipGene	associated	PD	12709726, 12844134, 14534524, 14553962, 15864129, 16109321, 16402084, 11787477, 12844134, 15861037, 16815314
PA444645	Ischemia	Disease	VipGene	associated		12090746, 16189366, 16210433, 11704005
PA445019	Myocardial Infarction	Disease	VipGene	associated		16189366, 12090746
PA445131	Obesity	Disease	VipGene	associated		15479221, 15685248, 15833937, 15917856, 12032746
PA446459	Myocardial Ischemia	Disease	VipGene	associated		12090746, 16189366, 16210433, 11704005
PA446916	Sleep Apnea, Obstructive	Disease	VipGene	associated		16122377
PA447278	Depression	Disease	VipGene	associated		12815745
PA447288	Essential hypertension	Disease	VipGene	associated		12709726, 12844134, 14534524, 14553962, 15864129, 16109321, 16402084, 11787477
PA447300	Acquired Long QT Syndrome (aLQTS)	Disease	VipGene	associated		11942593
PA448011	acebutolol	Chemical	VipGene	associated
PA448499	atenolol	Chemical	ClinicalAnnotation, VipGene	associated	PD	12709726, 11787477, 12709726, 12844134, 12921807, 14502278, 14534524, 15735607, 15861037, 15864115, 16815314, 17496726, 18075464, 20235788, 20352314, 20643254, 21311897, 22617224
PA448641	bisoprolol	Chemical	VipGene	associated		16325050, 15861037
PA448817	carvedilol	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	associated	PD	12709726, 12844134, 12921807, 14502278, 14534524, 15735607, 15861037, 15864115, 16815314, 17496726, 18075464, 20235788, 20352314, 20643254, 21311897, 22617224, 27643874
PA449319	digoxin	Chemical	ClinicalAnnotation	associated	PD	22543981
PA449381	dobutamine	Chemical	ClinicalAnnotation, Pathway, VipGene	associated	PD	15564877, 16325050, 11753577, 15564877
PA449396	dopamine	Chemical	VipGene	associated
PA449470	epinephrine	Chemical	VipGene	associated
PA449899	hydrochlorothiazide	Chemical	VipGene	associated		15864129, 16109321, 14553962
PA450121	isoproterenol	Chemical	VariantAnnotation, VipGene	associated	PD	27643874
PA450480	metoprolol	Chemical	ClinicalAnnotation, VipGene	associated	PD	12921807, 14534524, 15735607, 15864115, 16402084, 12709726, 12844134, 12921807, 14502278, 14534524, 15735607, 15861037, 15864115, 16815314, 17496726, 18075464, 20235788, 20352314, 20643254, 21311897, 22617224
PA450649	norepinephrine	Chemical	VipGene	associated		12383575
PA451483	spironolactone	Chemical	ClinicalAnnotation	associated	PD	22543981
PA451690	timolol	Chemical	ClinicalAnnotation	associated	PD	16315032
PA452229	antidepressants	Chemical	VipGene	associated		12815745
PA452604	xenobiotics	Chemical	VipGene	associated		11942593

References

Pubmed ID	Year	Title	Citations
12244098	2002	Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer.	139
16844790	2006	A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure.	126
12374873	2002	Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.	100
14502278	2003	Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure.	97
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
12844134	2003	Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol.	68
12140284	2002	Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy.	58
16189366	2005	Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome.	54
18702968	2008	Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol.	52
19056576	2009	Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications.	49

Citation

Dessen P

ADRB1 (adrenoceptor beta 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47406/adrb1-(adrenoceptor-beta-1)