DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7)

2007-04-01  

Identity

HGNC
DNAJC7
LOCATION
17q21.2
LOCUSID
7266
ALIAS
DJ11,DJC7,TPR2,TTC2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7266
MIM: 601964
HGNC: 12392
Ensembl: ENSG00000168259

Variants:

dbSNP: 7266
ClinVar: 7266
TCGA: ENSG00000168259
COSMIC: DNAJC7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168259ENST00000316603Q99615
ENSG00000168259ENST00000426588Q99615
ENSG00000168259ENST00000457167Q99615
ENSG00000168259ENST00000585866K7ENB7
ENSG00000168259ENST00000586335K7EJ24
ENSG00000168259ENST00000587727K7EQ73
ENSG00000168259ENST00000588641K7ESP1
ENSG00000168259ENST00000588814K7ELJ8
ENSG00000168259ENST00000589576K7ER44
ENSG00000168259ENST00000589586K7EN19
ENSG00000168259ENST00000589773K7EJL5
ENSG00000168259ENST00000589810K7EPP7
ENSG00000168259ENST00000590348K7EIH8
ENSG00000168259ENST00000590774K7EJV7
ENSG00000168259ENST00000590886K7EK03
ENSG00000168259ENST00000591787K7EJE9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
128534762003Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.38
206614462010Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors.37
186204202008Role of the cochaperone Tpr2 in Hsp90 chaperoning.15
232614152013Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM2.8
247892012014Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system.4
317680502019Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein.4
269935972016Reduced cytosolic carboxypeptidase 6 (CCP6) level leads to accumulation of serum polyglutamylated DNAJC7 protein: A potential biomarker for renal cell carcinoma early detection.1

Citation

Dessen P

DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47420/dnajc7-(dnaj-heat-shock-protein-family-(hsp40)-member-c7)