RGS8 (regulator of G protein signaling 8)

2007-04-01 Affiliation

Identity

HGNC

RGS8

LOCATION

1q25.3

LOCUSID

85397

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 85397
MIM: 607189
HGNC: 16810
Ensembl: ENSG00000135824

Variants:

dbSNP: 85397
ClinVar: 85397
TCGA: ENSG00000135824
COSMIC: RGS8

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135824	ENST00000258302	P57771
ENSG00000135824	ENST00000367556	P57771
ENSG00000135824	ENST00000367557	P57771
ENSG00000135824	ENST00000483095	P57771
ENSG00000135824	ENST00000508450	D6RD36

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Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
G alpha (i) signalling events	REACTOME	R-HSA-418594
GPCR downstream signaling	REACTOME	R-HSA-388396
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18262772	2008	Association of RGS2 and RGS5 variants with schizophrenia symptom severity.	17
18262772	2008	Association of RGS2 and RGS5 variants with schizophrenia symptom severity.	17
18834863	2008	Spinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8.	4
18834863	2008	Spinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8.	4
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20627871	2010	Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.	7
20627871	2010	Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.	7
21135262	2011	High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer.	8
21135262	2011	High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer.	8

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Citation

Dessen P

RGS8 (regulator of G protein signaling 8)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47429/rgs8-(regulator-of-g-protein-signaling-8)