SESN2 (sestrin 2)

2007-04-01  

Identity

HGNC
SESN2
LOCATION
1p35.3
LOCUSID
83667
ALIAS
HI95,SES2,SEST2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83667
MIM: 607767
HGNC: 20746
Ensembl: ENSG00000130766

Variants:

dbSNP: 83667
ClinVar: 83667
TCGA: ENSG00000130766
COSMIC: SESN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130766ENST00000253063P58004

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
mTOR signaling pathwayKEGGko04150
p53 signaling pathwayKEGGhsa04115
mTOR signaling pathwayKEGGhsa04150
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Longevity regulating pathwayKEGGhsa04211

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
381655652024Sestrin2 ameliorates diabetic retinopathy by regulating autophagy and ferroptosis.2
383310082024Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion.1
383792152024Sestrin 2 protects human lens epithelial cells from oxidative stress and apoptosis induced by hydrogen peroxide by regulating the mTOR/Nrf2 pathway.0
381655652024Sestrin2 ameliorates diabetic retinopathy by regulating autophagy and ferroptosis.2
383310082024Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway after intestinal ischemia-reperfusion.1
383792152024Sestrin 2 protects human lens epithelial cells from oxidative stress and apoptosis induced by hydrogen peroxide by regulating the mTOR/Nrf2 pathway.0
360661092023Sestrin2 suppresses ferroptosis to alleviate septic intestinal inflammation and barrier dysfunction.3
366208772023Sestrin2 mediates FOXM1 expression to block the EMT process in non-small cell lung cancer through the AMPK/YAP pathway.1
368418242023Sestrin2: multifaceted functions, molecular basis, and its implications in liver diseases.5
369023102023Sestrin2 as a Protective Shield against Cardiovascular Disease.1
369809732023SESN2 Could Be a Potential Marker for Diagnosis and Prognosis in Glioma.1
379185782023Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation.0
380310412023Significance of serum sestrin2 as a biomarker of severity and functional outcome in acute intracerebral hemorrhage: a prospective observational longitudinal study.0
360661092023Sestrin2 suppresses ferroptosis to alleviate septic intestinal inflammation and barrier dysfunction.3
366208772023Sestrin2 mediates FOXM1 expression to block the EMT process in non-small cell lung cancer through the AMPK/YAP pathway.1

Citation

Dessen P

SESN2 (sestrin 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47453/sesn2-(sestrin-2)