Identity
HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
CAG3A,CTG3a,NBL,NUMB-R,NUMBLIKE,NUMBR,TNRC23
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9253
MIM: 604018
HGNC: 8061
Ensembl: ENSG00000105245
Variants:
dbSNP: 9253
ClinVar: 9253
TCGA: ENSG00000105245
COSMIC: NUMBL
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Notch signaling pathway | KEGG | ko04330 |
| Notch signaling pathway | KEGG | hsa04330 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35599603 | 2022 | SLC8A1 antisense RNA 1 suppresses papillary thyroid cancer malignant progression via the FUS RNA binding protein (FUS)/NUMB like endocytic adaptor protein (Numbl) axis. | 6 |
| 35599603 | 2022 | SLC8A1 antisense RNA 1 suppresses papillary thyroid cancer malignant progression via the FUS RNA binding protein (FUS)/NUMB like endocytic adaptor protein (Numbl) axis. | 6 |
| 28067668 | 2017 | Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. | 27 |
| 28067668 | 2017 | Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation. | 27 |
| 27383182 | 2016 | Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis. | 17 |
| 27521217 | 2016 | Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl. | 35 |
| 27613838 | 2016 | Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy. | 27 |
| 27383182 | 2016 | Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis. | 17 |
| 27521217 | 2016 | Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl. | 35 |
| 27613838 | 2016 | Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy. | 27 |
| 26069237 | 2015 | Regulation of vascular endothelial growth factor receptor function in angiogenesis by numb and numb-like. | 10 |
| 26069237 | 2015 | Regulation of vascular endothelial growth factor receptor function in angiogenesis by numb and numb-like. | 10 |
| 23440423 | 2013 | Regulation of lung cancer metastasis by Klf4-Numb-like signaling. | 32 |
| 23681800 | 2013 | Numblike regulates proliferation, apoptosis, and invasion of lung cancer cell. | 8 |
| 23440423 | 2013 | Regulation of lung cancer metastasis by Klf4-Numb-like signaling. | 32 |
Citation
Dessen P
NUMBL (NUMB like endocytic adaptor protein)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47456/numbl-(numb-like-endocytic-adaptor-protein)
