Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10526
MIM: 605600
HGNC: 9853
Ensembl: ENSG00000133704
Variants:
dbSNP: 10526
ClinVar: 10526
TCGA: ENSG00000133704
COSMIC: IPO8
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| Gene Silencing by RNA | REACTOME | R-HSA-211000 |
| Transcriptional regulation by small RNAs | REACTOME | R-HSA-5578749 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34010604 | 2021 | Bi-allelic variants in IPO8 cause a connective tissue disorder associated with cardiovascular defects, skeletal abnormalities, and immune dysregulation. | 7 |
| 34010605 | 2021 | A human importin-β-related disorder: Syndromic thoracic aortic aneurysm caused by bi-allelic loss-of-function variants in IPO8. | 6 |
| 34010604 | 2021 | Bi-allelic variants in IPO8 cause a connective tissue disorder associated with cardiovascular defects, skeletal abnormalities, and immune dysregulation. | 7 |
| 34010605 | 2021 | A human importin-β-related disorder: Syndromic thoracic aortic aneurysm caused by bi-allelic loss-of-function variants in IPO8. | 6 |
| 27114554 | 2016 | Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E. | 38 |
| 27277970 | 2016 | RUNX2 controls human IPO8 basal transcription in Saos-2 cells. | 0 |
| 27114554 | 2016 | Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E. | 38 |
| 27277970 | 2016 | RUNX2 controls human IPO8 basal transcription in Saos-2 cells. | 0 |
| 26220098 | 2015 | Functional characterization of importin α8 as a classical nuclear localization signal receptor. | 10 |
| 26220098 | 2015 | Functional characterization of importin α8 as a classical nuclear localization signal receptor. | 10 |
| 23906023 | 2013 | KPNB1, XPO7 and IPO8 mediate the translocation ofNF-κB/p65 into the nucleus. | 50 |
| 23906023 | 2013 | KPNB1, XPO7 and IPO8 mediate the translocation ofNF-κB/p65 into the nucleus. | 50 |
| 19167051 | 2009 | Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. | 171 |
| 19167051 | 2009 | Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. | 171 |
| 18519565 | 2008 | Preferential utilization of Imp7/8 in nuclear import of Smads. | 42 |
Citation
Dessen P
IPO8 (importin 8)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47460/ipo8-(importin-8)
