Identity
HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
AIP2,WWp2-like
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11060
MIM: 602308
HGNC: 16804
Ensembl: ENSG00000198373
Variants:
dbSNP: 11060
ClinVar: 11060
TCGA: ENSG00000198373
COSMIC: WWP2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Ubiquitin mediated proteolysis | KEGG | ko04120 |
| Ubiquitin mediated proteolysis | KEGG | hsa04120 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37921219 | 2024 | WWP2 binds to NKRF, enhances the NF-κB signaling, and promotes malignant phenotypes of acute myeloid leukemia cells. | 0 |
| 37921219 | 2024 | WWP2 binds to NKRF, enhances the NF-κB signaling, and promotes malignant phenotypes of acute myeloid leukemia cells. | 0 |
| 36208715 | 2023 | WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes. | 3 |
| 36773333 | 2023 | Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1. | 1 |
| 36795754 | 2023 | lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1. | 9 |
| 36803368 | 2023 | WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein. | 3 |
| 37149668 | 2023 | Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X. | 2 |
| 36208715 | 2023 | WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes. | 3 |
| 36773333 | 2023 | Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1. | 1 |
| 36795754 | 2023 | lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1. | 9 |
| 36803368 | 2023 | WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein. | 3 |
| 37149668 | 2023 | Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X. | 2 |
| 35331737 | 2022 | Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates. | 4 |
| 35880837 | 2022 | WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma. | 3 |
| 35983977 | 2022 | WWP2 ameliorates oxidative stress and inflammation in atherosclerotic mice through regulation of PDCD4/HO-1 pathway. | 4 |
Citation
Dessen P
WWP2 (WW domain containing E3 ubiquitin protein ligase 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47485/wwp2-(ww-domain-containing-e3-ubiquitin-protein-ligase-2)
