CAGE1 (cancer-associated gene-1)
2003-07-01 Jean-Loup Huret , Sylvie Senon AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Identity
HGNC
LOCATION
6p24.3
LOCUSID
ALIAS
CT3,CT95,CTAG3,bA69L16.7
FUSION GENES
DNA/RNA
Description
spans 63 kb; 11 exons; ORF: 1920 bp
Proteins
Expression
testis-restricted in normal tissues; wide/high expression in various cancer tissues (lung, cervix, stomach) CAG1 is a probable member of the cancer/testis antigen family
Localisation
mainly nuclear
Function
may be involved in signaling pathway
Homology
with monkey genes with testis specific expression
Mutations
Somatic
may be associated with tumor progression .
Implicated in
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 12531476 | 2003 | Identification and characterization of a novel cancer/testis antigen gene CAGE-1. | Park S et al |
Other Information
Locus ID:
NCBI: 285782
MIM: 608304
HGNC: 21622
Ensembl: ENSG00000164304
Variants:
dbSNP: 285782
ClinVar: 285782
TCGA: ENSG00000164304
COSMIC: CAGE1
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 24174534 | 2013 | miR-200b and cancer/testis antigen CAGE form a feedback loop to regulate the invasion and tumorigenic and angiogenic responses of a cancer cell line to microtubule-targeting drugs. | 24 |
| 24174534 | 2013 | miR-200b and cancer/testis antigen CAGE form a feedback loop to regulate the invasion and tumorigenic and angiogenic responses of a cancer cell line to microtubule-targeting drugs. | 24 |
| 17786288 | 2007 | High frequency of promoter methylation of the 14-3-3 sigma and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder. | 6 |
| 17786288 | 2007 | High frequency of promoter methylation of the 14-3-3 sigma and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder. | 6 |
| 16964403 | 2006 | Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas. | 16 |
| 17114284 | 2006 | Characterization of a cancer/testis (CT) antigen gene family capable of eliciting humoral response in cancer patients. | 12 |
| 16964403 | 2006 | Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas. | 16 |
| 17114284 | 2006 | Characterization of a cancer/testis (CT) antigen gene family capable of eliciting humoral response in cancer patients. | 12 |
| 12531476 | 2003 | Identification and characterization of a novel cancer/testis antigen gene CAGE-1. | 13 |
| 12531476 | 2003 | Identification and characterization of a novel cancer/testis antigen gene CAGE-1. | 13 |
Citation
Jean-Loup Huret ; Sylvie Senon
CAGE1 (cancer-associated gene-1)
Atlas Genet Cytogenet Oncol Haematol. 2003-07-01
Online version: http://atlasgeneticsoncology.org/gene/475/cage1-(cancer-associated-gene-1)
