METTL16 (methyltransferase 16, N6-methyladenosine)

2007-04-01  

Identity

HGNC
METTL16
LOCATION
17p13.3
LOCUSID
79066
ALIAS
METT10D
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79066
HGNC: 28484
Ensembl: ENSG00000127804

Variants:

dbSNP: 79066
ClinVar: 79066
TCGA: ENSG00000127804
COSMIC: METTL16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127804ENST00000263092Q86W50
ENSG00000127804ENST00000571298K7EKQ8
ENSG00000127804ENST00000574752I3L362
ENSG00000127804ENST00000576556I3L3W3
ENSG00000127804ENST00000576976I3L4V1

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
373575262024METTL16 promotes osteosarcoma progression by downregulating VPS33B in an m(6) A-dependent manner.4
380847912024METTL16-mediated N6-methyladenosine modification of Soga1 enables proper chromosome segregation and chromosomal stability in colorectal cancer.1
381312262024Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review).0
383029922024METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation.3
383347972024METTL16 inhibits papillary thyroid cancer tumorigenicity through m(6)A/YTHDC2/SCD1-regulated lipid metabolism.1
383850842024METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway.0
373575262024METTL16 promotes osteosarcoma progression by downregulating VPS33B in an m(6) A-dependent manner.4
380847912024METTL16-mediated N6-methyladenosine modification of Soga1 enables proper chromosome segregation and chromosomal stability in colorectal cancer.1
381312262024Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review).0
383029922024METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation.3
383347972024METTL16 inhibits papillary thyroid cancer tumorigenicity through m(6)A/YTHDC2/SCD1-regulated lipid metabolism.1
383850842024METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway.0
364349042023METTL16 epigenetically enhances GPX4 expression via m6A modification to promote breast cancer progression by inhibiting ferroptosis.17
365842912023Elucidating the Kinetic Mechanism of Human METTL16.7
366086792023METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.29

Citation

Dessen P

METTL16 (methyltransferase 16, N6-methyladenosine)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47510