RGS17 (regulator of G-protein signaling 17)
2011-10-01 Chenguang Li , Lei Wang , Yihua Sun , Haiquan Chen AffiliationDepartment of Thoracic Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China
Identity
HGNC
LOCATION
6q25.2
LOCUSID
ALIAS
RGS-17,RGSZ2,hRGS17
FUSION GENES
DNA/RNA
Description
The RGS17 gene spans over a region of 120 kbp DNA including 4 coding exons and 1 non-coding exon (exon 1).
Transcription
The RGS17 gene mRNA consists of about 1472 nucleotides with an open reading frame (ORF) of 633 bases.
Pseudogene
RGS17P1 regulator of G-protein signaling 17 pseudogene 1.
Proteins
Note
210 amino acids; 24 kDa.
Diagram of the RGS17 protein in scale. The numbers represent specific residues. The regions are RGS_RZ-like (Regulator of G protein signaling (RGS) domain found in the RZ protein), putative G-alpha interaction site. C: Carboxyl-terminal; N: Amino-terminal.
Description
The RGS17 protein consists of 210 amino acid residues. This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region.
Expression
Widely expressed in human organs.
Localisation
Its cellular localization has not been formally monitored to date.
Function
The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. RGS proteins are GTPase-activating proteins for Gi and Gq class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
Homology
The RGS17 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish.
Mutations
Germinal
No germline mutations in this gene have been reported.
Somatic
A synonymous-coding somatic mutations of this gene is reported in pancreas cancer at codon 166, P166P (COSMIC).
Implicated in
Entity name
Various cancer
Note
Lung cancer, prostate cancer.
Disease
RSG17 is overexpressed in lung and prostate cancer (James et al., 2009). Expression of RGS17 is up-regulated in 80% of lung tumors, and also up-regulated in prostate tumors. Overexpression of RGS17 induce and maintain cell proliferation.
Entity name
Lung cancer
Disease
hsa-mir-182 is involved in the down regulation of RGS17 expression through two conserved sites located in its 3 UTR region (Sun et al., 2010).
Two SNPs in the first intron of RGS17 (rs4083914 and rs9479510) were found associated with familial lung cancer susceptibility (You et al., 2009).
Two SNPs in the first intron of RGS17 (rs4083914 and rs9479510) were found associated with familial lung cancer susceptibility (You et al., 2009).
Entity name
Ovarian cancer
Disease
Prognosis
RGS17 loss of expression contributes to the development of chemoresistance in ovarian cancer cells.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 21044322 | 2010 | Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells. | Hooks SB et al |
| 19244110 | 2009 | RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway. | James MA et al |
| 20420807 | 2010 | Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro. | Sun Y et al |
| 19351763 | 2009 | Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. | You M et al |
Other Information
Locus ID:
NCBI: 26575
MIM: 607191
HGNC: 14088
Ensembl: ENSG00000091844
Variants:
dbSNP: 26575
ClinVar: 26575
TCGA: ENSG00000091844
COSMIC: RGS17
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000091844 | ENST00000206262 | Q9UGC6 |
| ENSG00000091844 | ENST00000367225 | Q9UGC6 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by GPCR | REACTOME | R-HSA-372790 |
| GPCR downstream signaling | REACTOME | R-HSA-388396 |
| G alpha (z) signalling events | REACTOME | R-HSA-418597 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | ||
| PA452229 | antidepressants | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37094862 | 2023 | Hsa_circ_0000285-Mediated miR-599/RGS17 Axis Participates in the Pathogenesis of Abdominal Aortic Aneurysm by Regulating the Functions of Vascular Smooth Muscle Cells. | 0 |
| 37094862 | 2023 | Hsa_circ_0000285-Mediated miR-599/RGS17 Axis Participates in the Pathogenesis of Abdominal Aortic Aneurysm by Regulating the Functions of Vascular Smooth Muscle Cells. | 0 |
| 34002599 | 2021 | MiR-203 inhibits cell proliferation, invasion, and migration of ovarian cancer through regulating RGS17. | 4 |
| 34002599 | 2021 | MiR-203 inhibits cell proliferation, invasion, and migration of ovarian cancer through regulating RGS17. | 4 |
| 30940727 | 2019 | High-resolution structure of RGS17 suggests a role for Ca(2+) in promoting the GTPase-activating protein activity by RZ subfamily members. | 2 |
| 31081094 | 2019 | MiRNA-199 inhibits malignant progression of lung cancer through mediating RGS17. | 11 |
| 31454494 | 2019 | Long non-coding RNA Linc00483 accelerated tumorigenesis of cervical cancer by regulating miR-508-3p/RGS17 axis. | 14 |
| 30940727 | 2019 | High-resolution structure of RGS17 suggests a role for Ca(2+) in promoting the GTPase-activating protein activity by RZ subfamily members. | 2 |
| 31081094 | 2019 | MiRNA-199 inhibits malignant progression of lung cancer through mediating RGS17. | 11 |
| 31454494 | 2019 | Long non-coding RNA Linc00483 accelerated tumorigenesis of cervical cancer by regulating miR-508-3p/RGS17 axis. | 14 |
| 28337960 | 2018 | G-Protein Signaling Protein-17 (RGS17) Is Upregulated and Promotes Tumor Growth and Migration in Human Colorectal Carcinoma. | 4 |
| 29351497 | 2018 | Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures. | 2 |
| 29559347 | 2018 | MicroRNA-199 suppresses cell proliferation, migration and invasion by downregulating RGS17 in hepatocellular carcinoma. | 21 |
| 28337960 | 2018 | G-Protein Signaling Protein-17 (RGS17) Is Upregulated and Promotes Tumor Growth and Migration in Human Colorectal Carcinoma. | 4 |
| 29351497 | 2018 | Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures. | 2 |
Citation
Chenguang Li ; Lei Wang ; Yihua Sun ; Haiquan Chen
RGS17 (regulator of G-protein signaling 17)
Atlas Genet Cytogenet Oncol Haematol. 2011-10-01
Online version: http://atlasgeneticsoncology.org/gene/47522/rgs17-(regulator-of-g-protein-signaling-17)
