DHRS4 (dehydrogenase/reductase 4)

2007-05-01  

Identity

HGNC
DHRS4
LOCATION
14q11.2
LOCUSID
10901
ALIAS
CR,NRDR,PHCR,PSCD,SCAD-SRL,SDR-SRL,SDR25C1,SDR25C2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10901
MIM: 611596
HGNC: 16985
Ensembl: ENSG00000157326

Variants:

dbSNP: 10901
ClinVar: 10901
TCGA: ENSG00000157326
COSMIC: DHRS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157326ENST00000313250Q9BTZ2
ENSG00000157326ENST00000397074Q9BTZ2
ENSG00000157326ENST00000397075Q9BTZ2
ENSG00000157326ENST00000543741F5GWZ1
ENSG00000157326ENST00000558263Q9BTZ2
ENSG00000157326ENST00000558581Q9BTZ2
ENSG00000157326ENST00000559632Q9BTZ2
ENSG00000157326ENST00000559975H0YNP7

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Retinol metabolismKEGGko00830
Retinol metabolismKEGGhsa00830
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
RA biosynthesis pathwayREACTOMER-HSA-5365859

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
346666132021LncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by suppressing proliferation and promoting apoptosis via miR-522-3p/SOCS5 axis.16
346666132021LncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by suppressing proliferation and promoting apoptosis via miR-522-3p/SOCS5 axis.16
268649442016Enhancer RNA-driven looping enhances the transcription of the long noncoding RNA DHRS4-AS1, a controller of the DHRS4 gene cluster.29
273231172016CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription.2
268649442016Enhancer RNA-driven looping enhances the transcription of the long noncoding RNA DHRS4-AS1, a controller of the DHRS4 gene cluster.29
273231172016CpG island evolution in the mammalian DHRS4 gene cluster and its role in the regulation of gene transcription.2
228913342012AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans.48
230367052012Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.14
230367052012Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.14
231285272012Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent retinol dehydrogenase/reductase enhanced enzymatic activity of benzil.1
228913342012AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans.48
230367052012Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.14
230367052012Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.14
231285272012Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent retinol dehydrogenase/reductase enhanced enzymatic activity of benzil.1
205252262010Bioinformatic analysis of the human DHRS4 gene cluster and a proposed mechanism for its transcriptional regulation.3

Citation

Dessen P

DHRS4 (dehydrogenase/reductase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-05-01

Online version: http://atlasgeneticsoncology.org/gene/47526/dhrs4-(dehydrogenase-reductase-4)