NID1 (nidogen 1)

2007-05-01  

Identity

HGNC
LOCATION
1q42.3
LOCUSID
ALIAS
NID
FUSION GENES

Other Information

Locus ID:

NCBI: 4811
MIM: 131390
HGNC: 7821
Ensembl: ENSG00000116962

Variants:

dbSNP: 4811
ClinVar: 4811
TCGA: ENSG00000116962
COSMIC: NID1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116962ENST00000264187P14543
ENSG00000116962ENST00000366595P14543

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Laminin interactionsREACTOMER-HSA-3000157
Degradation of the extracellular matrixREACTOMER-HSA-1474228

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
173287942007Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer.26
214784942011Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk.25
259248022015Nidogen 1 and Nuclear Protein 1: novel targets of ETV5 transcription factor involved in endometrial cancer invasion.15
284167702017NID1, a new regulator of EMT required for metastasis and chemoresistance of ovarian cancer cells.15
236819362013Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on nidogen-1 and nidogen-2.12
170088822007Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic coculture.11
288273992017Identification of Nidogen 1 as a lung metastasis protein through secretome analysis.11
229526932012Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners.10
282825452017Nidogen-1 Degraded by Cathepsin S can be Quantified in Serum and is Associated with Non-Small Cell Lung Cancer.10
236744782013Mutations in extracellular matrix genes NID1 and LAMC1 cause autosomal dominant Dandy-Walker malformation and occipital cephaloceles.8

Citation

Dessen P

NID1 (nidogen 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-05-01

Online version: http://atlasgeneticsoncology.org/gene/47530/nid1-(nidogen-1)