NID2 (nidogen 2)

2007-05-01  

Identity

HGNC
LOCATION
14q22.1
LOCUSID
ALIAS
NID-2
FUSION GENES

Other Information

Locus ID:

NCBI: 22795
MIM: 605399
HGNC: 13389
Ensembl: ENSG00000087303

Variants:

dbSNP: 22795
ClinVar: 22795
TCGA: ENSG00000087303
COSMIC: NID2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087303ENST00000216286Q14112
ENSG00000087303ENST00000556572H0YJV3
ENSG00000087303ENST00000617139A0A087WZP6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Laminin interactionsREACTOMER-HSA-3000157

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
215584112011NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva.44
117339942001Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins.32
173287942007Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer.26
124756452002Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice.24
236819362013Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on nidogen-1 and nidogen-2.12
170088822007Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic coculture.11
198836382010Nidogen-2: a new serum biomarker for ovarian cancer.10
236826132013Hypermethylation of TWIST1 and NID2 in tumor tissues and voided urine in urinary bladder cancer patients.9
266836632016Laminins and Nidogens in the Pericellular Matrix of Chondrocytes: Their Role in Osteoarthritis and Chondrogenic Differentiation.9
277930112016Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathogenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma.8

Citation

Dessen P

NID2 (nidogen 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-05-01

Online version: http://atlasgeneticsoncology.org/gene/47531/nid2-(nidogen-2)