EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific)

2007-06-01  

Identity

HGNC
LOCATION
3q21.3
LOCUSID
ALIAS
EFSEC,SELB
FUSION GENES

Other Information

Locus ID:

NCBI: 60678
MIM: 607695
HGNC: 24614
Ensembl: ENSG00000132394

Variants:

dbSNP: 60678
ClinVar: 60678
TCGA: ENSG00000132394
COSMIC: EEFSEC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132394ENST00000254730P57772
ENSG00000132394ENST00000483457C9J8T0

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Selenocysteine synthesisREACTOMER-HSA-2408557

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197677542009Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.191
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
288770312017Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.45
288770312017Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.45
189482682008A novel protein domain induces high affinity selenocysteine insertion sequence binding and elongation factor recruitment.28
208789502011Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
277082572016Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation.4

Citation

Dessen P

EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific)

Atlas Genet Cytogenet Oncol Haematol. 2007-06-01

Online version: http://atlasgeneticsoncology.org/gene/47554/eefsec-(eukaryotic-elongation-factor-selenocysteine-trna-specific)