CTNNA3 (catenin alpha 3)

2007-06-01  

Identity

HGNC
CTNNA3
LOCATION
10q21.3
LOCUSID
29119
ALIAS
ARVD13,VR22
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29119
MIM: 607667
HGNC: 2511
Ensembl: ENSG00000183230

Variants:

dbSNP: 29119
ClinVar: 29119
TCGA: ENSG00000183230
COSMIC: CTNNA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183230ENST00000330298Q5SW23
ENSG00000183230ENST00000433211Q9UI47
ENSG00000183230ENST00000494580V9GYW4
ENSG00000183230ENST00000545309F2Z2R0

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Adherens junctionKEGGko04520
Leukocyte transendothelial migrationKEGGko04670
Endometrial cancerKEGGko05213
Adherens junctionKEGGhsa04520
Leukocyte transendothelial migrationKEGGhsa04670
Pathways in cancerKEGGhsa05200
Endometrial cancerKEGGhsa05213
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
205465942010An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings.71
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
231364032013Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy.56
233581602014Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci.51
215628502012MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility.49
175358492007A unique and specific interaction between alphaT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs.48
191873322009Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis.38
191873322009Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis.38

Citation

Dessen P

CTNNA3 (catenin alpha 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-06-01

Online version: http://atlasgeneticsoncology.org/gene/47565/ctnna3-(catenin-alpha-3)