UIMC1 (ubiquitin interaction motif containing 1)

2007-06-01  

Identity

HGNC
UIMC1
LOCATION
5q35.2
LOCUSID
51720
ALIAS
RAP80,X2HRIP110
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51720
MIM: 609433
HGNC: 30298
Ensembl: ENSG00000087206

Variants:

dbSNP: 51720
ClinVar: 51720
TCGA: ENSG00000087206
COSMIC: UIMC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087206ENST00000377227Q96RL1
ENSG00000087206ENST00000377227A0A024R7R0
ENSG00000087206ENST00000428382D6R9M3
ENSG00000087206ENST00000506128Q96RL1
ENSG00000087206ENST00000507513D6RDZ5
ENSG00000087206ENST00000509236D6RC40
ENSG00000087206ENST00000510698Q96RL1
ENSG00000087206ENST00000511320Q96RL1
ENSG00000087206ENST00000511320A0A024R7R0
ENSG00000087206ENST00000512031D6RCQ3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Homologous recombinationKEGGhsa03440
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571
DeubiquitinationREACTOMER-HSA-5688426
Metalloprotease DUBsREACTOMER-HSA-5689901

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
351085302022RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair.4
351085302022RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair.4
319324212020RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci.8
319324212020RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci.8
312535742019Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.32
312535742019Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.32
293965162018RAP80 is an independent prognosis biomarker for the outcome of patients with esophageal squamous cell carcinoma.11
293965162018RAP80 is an independent prognosis biomarker for the outcome of patients with esophageal squamous cell carcinoma.11
274434202017Low RAP80 mRNA expression correlates with shorter survival in sporadic high-grade serous ovarian carcinoma.0
285698382017USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response.59
288422502017RAP80 binds p32 to preserve the functional integrity of mitochondria.3
274434202017Low RAP80 mRNA expression correlates with shorter survival in sporadic high-grade serous ovarian carcinoma.0
285698382017USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response.59
288422502017RAP80 binds p32 to preserve the functional integrity of mitochondria.3
264469862016Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells.48

Citation

Dessen P

UIMC1 (ubiquitin interaction motif containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-06-01

Online version: http://atlasgeneticsoncology.org/gene/47566/uimc1-(ubiquitin-interaction-motif-containing-1)