ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase)

2007-06-01  

Identity

HGNC
LOCATION
Xq13.1
LOCUSID
ALIAS
PICH,RAD26L

Other Information

Locus ID:

NCBI: 54821
MIM: 300687
HGNC: 20794
Ensembl: ENSG00000186871

Variants:

dbSNP: 54821
ClinVar: 54821
TCGA: ENSG00000186871
COSMIC: ERCC6L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186871ENST00000334463Q2NKX8
ENSG00000186871ENST00000373657B5MDQ0

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
172182582007PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint.140
179569452007Depletion of topoisomerase IIalpha leads to shortening of the metaphase interkinetochore distance and abnormal persistence of PICH-coated anaphase threads.41
217434382011PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution.36
199045492010Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs.33
239733282013PICH: a DNA translocase specially adapted for processing anaphase bridge DNA.33
266431432015PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis.30
225633702012Bloom's syndrome and PICH helicases cooperate with topoisomerase IIα in centromere disjunction before anaphase.25
201300822010PICH and cotargeted Plk1 coordinately maintain prometaphase chromosome arm architecture.18
184180762008Targeting Plk1 to chromosome arms and regulating chromosome compaction by the PICH ATPase.12
255646102015SUMOylation regulates polo-like kinase 1-interacting checkpoint helicase (PICH) during mitosis.12

Citation

Dessen P

ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase)

Atlas Genet Cytogenet Oncol Haematol. 2007-06-01

Online version: http://atlasgeneticsoncology.org/gene/47567/ercc6l-(ercc-excision-repair-6-like-spindle-assembly-checkpoint-helicase)