APLN (apelin)

2007-07-01 Affiliation

Identity

HGNC

APLN

LOCATION

Xq26.1

LOCUSID

8862

ALIAS

APEL,XNPEP2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8862
MIM: 300297
HGNC: 16665
Ensembl: ENSG00000171388

Variants:

dbSNP: 8862
ClinVar: 8862
TCGA: ENSG00000171388
COSMIC: APLN

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000171388	ENST00000429967	Q9ULZ1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
Apelin signaling pathway	KEGG	hsa04371

References

Pubmed ID	Year	Title	Citations
15677759	2005	Apelin, a newly identified adipokine up-regulated by insulin and obesity.	128
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
21821917	2011	Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival.	83
18772060	2008	Vascular effects of apelin in vivo in man.	74
15664671	2005	Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells.	72
12963638	2003	Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction.	67
18617693	2008	Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis.	64
19597036	2009	[Pyr1]apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease.	64
21233449	2011	Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension.	61
17412318	2007	Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis.	54

Citation

Dessen P

APLN (apelin)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47581/apln-(apelin)