PEPD (peptidase D)

2007-07-01  

Identity

HGNC
PEPD
LOCATION
19q13.11
LOCUSID
5184
ALIAS
PROLIDASE
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5184
MIM: 613230
HGNC: 8840
Ensembl: ENSG00000124299

Variants:

dbSNP: 5184
ClinVar: 5184
TCGA: ENSG00000124299
COSMIC: PEPD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124299ENST00000244137P12955
ENSG00000124299ENST00000244137A0A140VJR2
ENSG00000124299ENST00000397032P12955
ENSG00000124299ENST00000436370P12955
ENSG00000124299ENST00000588328K7ES25
ENSG00000124299ENST00000590408V9GYL0
ENSG00000124299ENST00000590755V9GYE4
ENSG00000124299ENST00000651646A0A494C194
ENSG00000124299ENST00000651901A0A494C165

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381598572024KLF6 activates Sp1-mediated prolidase transcription during TGF-β(1) signaling.1
381598572024KLF6 activates Sp1-mediated prolidase transcription during TGF-β(1) signaling.1
365214002023Prolidase as a marker of fibrogenesis in idiopathic primary ovarian insufficiency.1
365214002023Prolidase as a marker of fibrogenesis in idiopathic primary ovarian insufficiency.1
365918222022The relationship between serum prolidase activity and histone H3 protein levels and fibromyalgia.0
365918222022The relationship between serum prolidase activity and histone H3 protein levels and fibromyalgia.0
327345982021Whole exome sequencing identifies three novel gene mutations in patients with the triad of diabetic ketoacidosis, hypertriglyceridemia, and acute pancreatitis.6
334778202021Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase.14
334778992021Extracellular Prolidase (PEPD) Induces Anabolic Processes through EGFR, β(1)-integrin, and IGF-1R Signaling Pathways in an Experimental Model of Wounded Fibroblasts.5
348804212021Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants.2
327345982021Whole exome sequencing identifies three novel gene mutations in patients with the triad of diabetic ketoacidosis, hypertriglyceridemia, and acute pancreatitis.6
334778202021Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase.14
334778992021Extracellular Prolidase (PEPD) Induces Anabolic Processes through EGFR, β(1)-integrin, and IGF-1R Signaling Pathways in an Experimental Model of Wounded Fibroblasts.5
348804212021Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants.2
325984842020Co-expression with chaperones can affect protein 3D structure as exemplified by loss-of-function variants of human prolidase.2

Citation

Dessen P

PEPD (peptidase D)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47595/pepd-(peptidase-d)