MRC2 (mannose receptor C type 2)

2007-07-01

Identity

HGNC

MRC2

LOCATION

17q23.2

LOCUSID

9902

ALIAS

CD280,CLEC13E,ENDO180,UPARAP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9902
MIM: 612264
HGNC: 16875
Ensembl: ENSG00000011028

Variants:

dbSNP: 9902
ClinVar: 9902
TCGA: ENSG00000011028
COSMIC: MRC2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000011028	ENST00000303375	Q9UBG0
ENSG00000011028	ENST00000446119	E7EME3
ENSG00000011028	ENST00000579432	J3QQZ6
ENSG00000011028	ENST00000584682	J3KRF1

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Adaptive Immune System	REACTOME	R-HSA-1280218
Antigen processing-Cross presentation	REACTOME	R-HSA-1236975
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Cross-presentation of soluble exogenous antigens (endosomes)	REACTOME	R-HSA-1236978
Immune System	REACTOME	R-HSA-168256
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
26466547	2016	Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180.	16
26466547	2016	Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180.	16
27247422	2016	Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding.	4
29061505	2018	Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180.	18
29061505	2018	Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180.	18
30366943	2019	Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins.	10
30366943	2019	Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins.	10
31376337	2020	Interleukin-1 alpha derived from ultraviolet B-exposed keratinocytes is associated with a decrease of endocytic collagen receptor Endo180.	1
31376337	2020	Interleukin-1 alpha derived from ultraviolet B-exposed keratinocytes is associated with a decrease of endocytic collagen receptor Endo180.	1
32072971	2020	Mathematical modelling of the role of Endo180 network in the development of metastatic bone disease in prostate cancer.	4

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Citation

Dessen P

MRC2 (mannose receptor C type 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47622