MRC2 (mannose receptor C type 2)

2007-07-01  

Identity

HGNC
MRC2
LOCATION
17q23.2
LOCUSID
9902
ALIAS
CD280,CLEC13E,ENDO180,UPARAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9902
MIM: 612264
HGNC: 16875
Ensembl: ENSG00000011028

Variants:

dbSNP: 9902
ClinVar: 9902
TCGA: ENSG00000011028
COSMIC: MRC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000011028ENST00000303375Q9UBG0
ENSG00000011028ENST00000446119E7EME3
ENSG00000011028ENST00000579432J3QQZ6
ENSG00000011028ENST00000584682J3KRF1

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
Cross-presentation of soluble exogenous antigens (endosomes)REACTOMER-HSA-1236978

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
340127642021MRC2 Promotes Proliferation and Inhibits Apoptosis of Diabetic Nephropathy.6
347688832021The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target.2
340127642021MRC2 Promotes Proliferation and Inhibits Apoptosis of Diabetic Nephropathy.6
347688832021The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target.2
313763372020Interleukin-1 alpha derived from ultraviolet B-exposed keratinocytes is associated with a decrease of endocytic collagen receptor Endo180.1
320729712020Mathematical modelling of the role of Endo180 network in the development of metastatic bone disease in prostate cancer.4
313763372020Interleukin-1 alpha derived from ultraviolet B-exposed keratinocytes is associated with a decrease of endocytic collagen receptor Endo180.1
320729712020Mathematical modelling of the role of Endo180 network in the development of metastatic bone disease in prostate cancer.4
303669432019Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins.10
303669432019Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins.10
290615052018Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180.18
290615052018Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180.18
264665472016Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180.16
272474222016Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding.4
264665472016Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180.16

Citation

Dessen P

MRC2 (mannose receptor C type 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47622/mrc2-(mannose-receptor-c-type-2)