ALYREF (Aly/REF export factor)

2007-07-01  

Identity

HGNC
ALYREF
LOCATION
17q25.3
LOCUSID
10189
ALIAS
ALY,ALY/REF,BEF,REF,THOC4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10189
MIM: 604171
HGNC: 19071
Ensembl: ENSG00000183684

Variants:

dbSNP: 10189
ClinVar: 10189
TCGA: ENSG00000183684
COSMIC: ALYREF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183684ENST00000505490E9PB61

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
RNA transportKEGGko03013
RNA transportKEGGhsa03013
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
TREX complexKEGGhsa_M00406
Exon junction complex (EJC)KEGGhsa_M00430
TREX complexKEGGM00406
Exon junction complex (EJC)KEGGM00430
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236
Transport of Mature mRNAs Derived from Intronless TranscriptsREACTOMER-HSA-159234
Transport of the SLBP Dependant Mature mRNAREACTOMER-HSA-159230
Transport of the SLBP independent Mature mRNAREACTOMER-HSA-159227
Transport of Mature mRNA Derived from an Intronless TranscriptREACTOMER-HSA-159231

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
159988062005Recruitment of the human TREX complex to mRNA during splicing.174
2841803820175-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C reader.93
191651462009Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.66
209810252010A role for TREX components in the release of spliced mRNA from nuclear speckle domains.58
232221302013Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA.49
185622792008Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY.38
193693542009The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensable.35
182431192008Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay.33
288015092017Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export.28
213295102011Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers.23

Citation

Dessen P

ALYREF (Aly/REF export factor)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47636/alyref-(aly-ref-export-factor)