ARL6IP5 (ADP ribosylation factor like GTPase 6 interacting protein 5)

2007-07-01  

Identity

HGNC
LOCATION
3p14.1
LOCUSID
ALIAS
DERP11,GTRAP3-18,HSPC127,JWA,PRAF3,Yip6b,addicsin,hp22,jmx
FUSION GENES

Other Information

Locus ID:

NCBI: 10550
MIM: 605709
HGNC: 16937
Ensembl: ENSG00000144746

Variants:

dbSNP: 10550
ClinVar: 10550
TCGA: ENSG00000144746
COSMIC: ARL6IP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144746ENST00000273258O75915
ENSG00000144746ENST00000273258A0A024R371
ENSG00000144746ENST00000478935C9JQU6
ENSG00000144746ENST00000484921F8WF33
ENSG00000144746ENST00000485444F8WF90

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Glutamate Neurotransmitter Release CycleREACTOMER-HSA-210500

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202019242010Genome-wide association study of alcohol dependence implicates a region on chromosome 11.159
224529402012Prognostic and predictive role of JWA and XRCC1 expressions in gastric cancer.37
181673562008The endoplasmic reticulum exit of glutamate transporter is regulated by the inducible mammalian Yip6b/GTRAP3-18 protein.27
173360412007JWA as a functional molecule to regulate cancer cells migration via MAPK cascades and F-actin cytoskeleton.25
254768992014JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells.25
240727722014JWA suppresses tumor angiogenesis via Sp1-activated matrix metalloproteinase-2 and its prognostic significance in human gastric cancer.21
231098972012Inhibition of GTRAP3-18 may increase neuroprotective glutathione (GSH) synthesis.17
176464252007Regulation of glutathione synthesis via interaction between glutamate transport-associated protein 3-18 (GTRAP3-18) and excitatory amino acid carrier-1 (EAAC1) at plasma membrane.14
164811312006Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2).10
164308622006JWA, a novel signaling molecule, involved in the induction of differentiation of human myeloid leukemia cells.9

Citation

Dessen P

ARL6IP5 (ADP ribosylation factor like GTPase 6 interacting protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47637/arl6ip5-(adp-ribosylation-factor-like-gtpase-6-interacting-protein-5)