NPBWR1 (neuropeptides B and W receptor 1)

2007-07-01  

Identity

HGNC
NPBWR1
LOCATION
8q11.23
LOCUSID
2831
ALIAS
GPR7

Other Information

Locus ID:

NCBI: 2831
MIM: 600730
HGNC: 4522
Ensembl: ENSG00000183729

Variants:

dbSNP: 2831
ClinVar: 2831
TCGA: ENSG00000183729
COSMIC: NPBWR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183729ENST00000331251P48145
ENSG00000183729ENST00000331251H9NIL7

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
235632482013Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese subjects.0
240819452013A prognostic DNA methylation signature for stage I non-small-cell lung cancer.138
235632482013Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese subjects.0
240819452013A prognostic DNA methylation signature for stage I non-small-cell lung cancer.138
225451052012A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions.13
225451052012A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions.13
174378062007Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis.43
174378062007Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis.43
156079412005Schwann cell overexpression of the GPR7 receptor in inflammatory and painful neuropathies.9
157979612005G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.14
156079412005Schwann cell overexpression of the GPR7 receptor in inflammatory and painful neuropathies.9
157979612005G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.14
124018092003Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.30
127195372003Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.51
124018092003Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.30

Citation

Dessen P

NPBWR1 (neuropeptides B and W receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47657/npbwr1-(neuropeptides-b-and-w-receptor-1)