DSG3 (desmoglein 3)

2007-07-01  

Identity

HGNC
LOCATION
18q12.1
LOCUSID
ALIAS
ABOLM,CDHF6,PVA
FUSION GENES

Other Information

Locus ID:

NCBI: 1830
MIM: 169615
HGNC: 3050
Ensembl: ENSG00000134757

Variants:

dbSNP: 1830
ClinVar: 1830
TCGA: ENSG00000134757
COSMIC: DSG3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134757ENST00000257189P32926

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Pathways

PathwaySourceExternal ID
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Apoptotic cleavage of cell adhesion proteinsREACTOMER-HSA-351906
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163776232006Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodies.77
184343192008Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanism.53
221897872012Desmoglein as a target in skin disease and beyond.52
186413202008Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction.47
229964512012Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface.44
168781572007DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis.39
200933682010p38MAPK signaling and desmoglein-3 internalization are linked events in pemphigus acantholysis.36
121381952002Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation.33
244982012014Desmosome assembly and disassembly are membrane raft-dependent.26
174288082007Anti-desmoglein 3 (Dsg3) monoclonal antibodies deplete desmosomes of Dsg3 and differ in their Dsg3-depleting activities related to pathogenicity.24

Citation

Dessen P

DSG3 (desmoglein 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47658/dsg3-(desmoglein-3)