G3BP1 (G3BP stress granule assembly factor 1)

2007-08-01  

Identity

HGNC
G3BP1
LOCATION
5q33.1
LOCUSID
10146
ALIAS
G3BP,HDH-VIII
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10146
MIM: 608431
HGNC: 30292
Ensembl: ENSG00000145907

Variants:

dbSNP: 10146
ClinVar: 10146
TCGA: ENSG00000145907
COSMIC: G3BP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145907ENST00000356245Q13283
ENSG00000145907ENST00000356245Q5U0Q1
ENSG00000145907ENST00000394123Q13283
ENSG00000145907ENST00000394123Q5U0Q1
ENSG00000145907ENST00000507878E5RIZ6
ENSG00000145907ENST00000517947E5RH00
ENSG00000145907ENST00000520006E5RI46
ENSG00000145907ENST00000520177Q13283
ENSG00000145907ENST00000520578E5RH42
ENSG00000145907ENST00000522367Q13283
ENSG00000145907ENST00000522666E5RH00
ENSG00000145907ENST00000522761E5RJU8
ENSG00000145907ENST00000523519E5RIF8
ENSG00000145907ENST00000627077E5RH00

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379316912024DHX38 enhances proliferation, metastasis, and EMT progression in NSCLC through the G3BP1-mediated MAPK pathway.2
385811202024A new tandem repeat-enriched lncRNA XLOC_008672 promotes gastric carcinogenesis by regulating G3BP1 expression.1
379316912024DHX38 enhances proliferation, metastasis, and EMT progression in NSCLC through the G3BP1-mediated MAPK pathway.2
385811202024A new tandem repeat-enriched lncRNA XLOC_008672 promotes gastric carcinogenesis by regulating G3BP1 expression.1
364506652023G3BP1 coordinates lysophagy activity to protect against compression-induced cell ferroptosis during intervertebral disc degeneration.5
365118982023The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits.5
366110042023G3BP1-dependent mechanism suppressing protein aggregation in Huntington's models and its demise upon stress granule assembly.3
366922172023Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.11
368069432023The force-dependent filamin A-G3BP1 interaction regulates phase-separated stress granule formation.2
371007982023Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex.6
371612912023Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH.6
373026962023TRIM25-mediated ubiquitination of G3BP1 regulates the proliferation and migration of human neuroblastoma cells.3
375162902023The DUSP domain of pseudophosphatase MK-STYX interacts with G3BP1 to decrease stress granules.1
379041492023Endometrial cancer (EC) derived G3BP1 overexpression and mutant promote EC tumorigenesis and metastasis via SPOP/ERα axis.0
364506652023G3BP1 coordinates lysophagy activity to protect against compression-induced cell ferroptosis during intervertebral disc degeneration.5

Citation

Dessen P

G3BP1 (G3BP stress granule assembly factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/gene/47699/g3bp1-(g3bp-stress-granule-assembly-factor-1)